TACSTD2 upregulation is an early reaction to lung infection

J 2022

TACSTD2 upregulation is an early reaction to lung infection

LENÁRT, Sára, Peter LENÁRT, Lucia KNOPFOVÁ, Hana KOTASOVÁ, Vendula PELKOVÁ et. al.

Basic information

Original name

TACSTD2 upregulation is an early reaction to lung infection

Authors

LENÁRT, Sára (203 Czech Republic, belonging to the institution), Peter LENÁRT (703 Slovakia, belonging to the institution), Lucia KNOPFOVÁ (203 Czech Republic, belonging to the institution), Hana KOTASOVÁ (203 Czech Republic, belonging to the institution), Vendula PELKOVÁ (203 Czech Republic, belonging to the institution), Veronika SEDLÁKOVÁ (203 Czech Republic, belonging to the institution), Ondřej VACEK (203 Czech Republic, belonging to the institution), Jana POKLUDOVÁ (203 Czech Republic, belonging to the institution), Vladimír ČAN (703 Slovakia), Jan ŠMARDA (203 Czech Republic, belonging to the institution), Karel SOUČEK (203 Czech Republic, belonging to the institution), Aleš HAMPL (203 Czech Republic, belonging to the institution) and Petr BENEŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Nature Scientific Reports, London, NATURE RESEARCH, 2022, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10700 1.7 Other natural sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600

RIV identification code

RIV/00216224:14310/22:00126036

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1038/s41598-022-13637-9

UT WoS

000809441100064

Keywords in English

INNATE IMMUNE-RESPONSE; NF-KAPPA-B; EXPRESSION ATLAS; VIRAL-INFECTION; BARRIER; CELLS; GENE; IDENTIFICATION; CANCER; MURINE

Abstract

V originále

TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved for cancer therapy, the physiological role of Trop2 is still not fully understood. In this article, we show that TACSTD2/Trop2 expression is evolutionarily conserved in lungs of various vertebrates. By analysis of publicly available transcriptomic data we demonstrate that TACSTD2 level consistently increases in lungs infected with miscellaneous, but mainly viral pathogens. Single cell and subpopulation based transcriptomic data revealed that the major source of TACSTD2 transcript are lung epithelial cells and their progenitors and that TACSTD2 is induced directly in lung epithelial cells following infection. Increase in TACSTD2 expression may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs.

Links

MUNI/A/1380/2021, interní kód MU

Name: Vytvoření 3D modelu plicní tkáně pro modelování plicních onemocnění a testování léčiv

Investor: Masaryk University

MUNI/A/1522/2020, interní kód MU

Name: Podpora výzkumné činnosti studentů molekulární biologie a genetiky 9 (Acronym: MBG9)

Investor: Masaryk University

MUNI/A/1689/2020, interní kód MU

Name: Zdroje pro tkáňové inženýrství 11 (Acronym: TissueEng 11)

Investor: Masaryk University

NV18-07-00073, research and development project

Name: c-Myb a jeho transkripční program ve fyziologických a patologických osteogenních procesech

Investor: Ministry of Health of the CR

Citovat

LENÁRT, Sára, Peter LENÁRT, Lucia KNOPFOVÁ, Hana KOTASOVÁ, Vendula PELKOVÁ, Veronika SEDLÁKOVÁ, Ondřej VACEK, Jana POKLUDOVÁ, Vladimír ČAN, Jan ŠMARDA, Karel SOUČEK, Aleš HAMPL and Petr BENEŠ. TACSTD2 upregulation is an early reaction to lung infection. Nature Scientific Reports. London: NATURE RESEARCH, 2022, vol. 12, No 1, p. 9583-9597. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-13637-9.

@article{1860591,
   author = {Lenárt, Sára and Lenárt, Peter and Knopfová, Lucia and Kotasová, Hana and Pelková, Vendula and Sedláková, Veronika and Vacek, Ondřej and Pokludová, Jana and Čan, Vladimír and Šmarda, Jan and Souček, Karel and Hampl, Aleš and Beneš, Petr},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-13637-9},
   keywords = {INNATE IMMUNE-RESPONSE; NF-KAPPA-B; EXPRESSION ATLAS; VIRAL-INFECTION; BARRIER; CELLS; GENE; IDENTIFICATION; CANCER; MURINE},
   language = {eng},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   title = {TACSTD2 upregulation is an early reaction to lung infection},
   url = {https://www.nature.com/articles/s41598-022-13637-9},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 1860591
AU  - Lenárt, Sára - Lenárt, Peter - Knopfová, Lucia - Kotasová, Hana - Pelková, Vendula - Sedláková, Veronika - Vacek, Ondřej - Pokludová, Jana - Čan, Vladimír - Šmarda, Jan - Souček, Karel - Hampl, Aleš - Beneš, Petr
PY  - 2022
TI  - TACSTD2 upregulation is an early reaction to lung infection
JF  - Nature Scientific Reports
VL  - 12
IS  - 1
SP  - 9583
EP  - 9583
PB  - NATURE RESEARCH
SN  - 20452322
KW  - INNATE IMMUNE-RESPONSE
KW  - NF-KAPPA-B
KW  - EXPRESSION ATLAS
KW  - VIRAL-INFECTION
KW  - BARRIER
KW  - CELLS
KW  - GENE
KW  - IDENTIFICATION
KW  - CANCER
KW  - MURINE
UR  - https://www.nature.com/articles/s41598-022-13637-9
N2  - TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved for cancer therapy, the physiological role of Trop2 is still not fully understood. In this article, we show that TACSTD2/Trop2 expression is evolutionarily conserved in lungs of various vertebrates. By analysis of publicly available transcriptomic data we demonstrate that TACSTD2 level consistently increases in lungs infected with miscellaneous, but mainly viral pathogens. Single cell and subpopulation based transcriptomic data revealed that the major source of TACSTD2 transcript are lung epithelial cells and their progenitors and that TACSTD2 is induced directly in lung epithelial cells following infection. Increase in TACSTD2 expression may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs.
ER  -

LENÁRT, Sára, Peter LENÁRT, Lucia KNOPFOVÁ, Hana KOTASOVÁ, Vendula PELKOVÁ, Veronika SEDLÁKOVÁ, Ondřej VACEK, Jana POKLUDOVÁ, Vladimír ČAN, Jan ŠMARDA, Karel SOUČEK, Aleš HAMPL and Petr BENEŠ. TACSTD2 upregulation is an early reaction to lung infection. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2022, vol.~12, No~1, p.~9583-9597. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-13637-9.

Detailed Information on Publication Record