The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments

SOLÁR, Peter, Alemeh ZAMANI, Klaudia LAKATOSOVÁ and Marek JOUKAL. The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments. FLUIDS AND BARRIERS OF THE CNS. LONDON: BMC, 2022, vol. 19, No 1, p. 1-79. ISSN 2045-8118. Available from: https://dx.doi.org/10.1186/s12987-022-00312-4.

Basic information

• Original name: The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
• Authors: SOLÁR, Peter (703 Slovakia, belonging to the institution), Alemeh ZAMANI (364 Islamic Republic of Iran, belonging to the institution), Klaudia LAKATOSOVÁ (703 Slovakia, belonging to the institution) and Marek JOUKAL (203 Czech Republic, guarantor, belonging to the institution).
• Edition: FLUIDS AND BARRIERS OF THE CNS, LONDON, BMC, 2022, 2045-8118.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30103 Neurosciences
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 7.300
• RIV identification code: RIV/00216224:14110/22:00126060
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1186/s12987-022-00312-4
• UT WoS: 000780995700001
• Keywords in English: Subarachnoid hemorrhage; Blood-brain barrier; Subarachnoid hemorrhage treatment; Neuronal injury; Neurovascular unit; Neuroinflammation
• Tags: 14110131, 14110514, rivok
• Tags: Reviewed

Abstract

The response of the blood-brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, and astrocytes that affect microglia, neurons, and vascular smooth muscle cells. SAH induces alterations in individual BBB cells, leading to brain homeostasis disruption. Recent experiments have uncovered many pathophysiological cascades affecting the BBB following SAH. Targeting some of these pathways is important for restoring brain function following SAH. BBB injury occurs immediately after SAH and has long-lasting consequences, but most changes in the pathophysiological cascades occur in the first few days following SAH. These changes determine the development of early brain injury as well as delayed cerebral ischemia. SAH-induced neuroprotection also plays an important role and weakens the negative impact of SAH. Supporting some of these beneficial cascades while attenuating the major pathophysiological pathways might be decisive in inhibiting the negative impact of bleeding in the subarachnoid space. In this review, we attempt a comprehensive overview of the current knowledge on the molecular and cellular changes in the BBB following SAH and their possible modulation by various drugs and substances.

Links

• EF16_027/0008360, research and development project: Name: Postdoc@MUNI
• MUNI/A/0975/2019, interní kód MU: Name: Studium změn ve strukturách nervové soustavy po poškození

Investor: Masaryk University, Category A

• MUNI/A/1520/2020, interní kód MU: Name: Změny ve strukturách nervové soustavy v reakci na poškození

Investor: Masaryk University

• ROZV/23/LF14/2019, interní kód MU: Name: Elektrofyziologická a imunohistochemická studie změn podmíněných neurozánětem ve spinálních gangliích neasociovaných s poškozeným periferním nervem

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects