The blood-brain barrier and the neurovascular unit in
subarachnoid hemorrhage: molecular events and potential
treatments

J 2022

The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments

SOLÁR, Peter, Alemeh ZAMANI, Klaudia LAKATOSOVÁ and Marek JOUKAL

Basic information

Original name

The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments

Authors

SOLÁR, Peter (703 Slovakia, belonging to the institution), Alemeh ZAMANI (364 Islamic Republic of Iran, belonging to the institution), Klaudia LAKATOSOVÁ (703 Slovakia, belonging to the institution) and Marek JOUKAL (203 Czech Republic, guarantor, belonging to the institution)

Edition

FLUIDS AND BARRIERS OF THE CNS, LONDON, BMC, 2022, 2045-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.300

RIV identification code

RIV/00216224:14110/22:00126060

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s12987-022-00312-4

UT WoS

000780995700001

Keywords in English

Subarachnoid hemorrhage; Blood-brain barrier; Subarachnoid hemorrhage treatment; Neuronal injury; Neurovascular unit; Neuroinflammation

Abstract

V originále

The response of the blood-brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, and astrocytes that affect microglia, neurons, and vascular smooth muscle cells. SAH induces alterations in individual BBB cells, leading to brain homeostasis disruption. Recent experiments have uncovered many pathophysiological cascades affecting the BBB following SAH. Targeting some of these pathways is important for restoring brain function following SAH. BBB injury occurs immediately after SAH and has long-lasting consequences, but most changes in the pathophysiological cascades occur in the first few days following SAH. These changes determine the development of early brain injury as well as delayed cerebral ischemia. SAH-induced neuroprotection also plays an important role and weakens the negative impact of SAH. Supporting some of these beneficial cascades while attenuating the major pathophysiological pathways might be decisive in inhibiting the negative impact of bleeding in the subarachnoid space. In this review, we attempt a comprehensive overview of the current knowledge on the molecular and cellular changes in the BBB following SAH and their possible modulation by various drugs and substances.

Links

EF16_027/0008360, research and development project

Name: Postdoc@MUNI

MUNI/A/0975/2019, interní kód MU

Name: Studium změn ve strukturách nervové soustavy po poškození

Investor: Masaryk University, Category A

MUNI/A/1520/2020, interní kód MU

Name: Změny ve strukturách nervové soustavy v reakci na poškození

Investor: Masaryk University

ROZV/23/LF14/2019, interní kód MU

Name: Elektrofyziologická a imunohistochemická studie změn podmíněných neurozánětem ve spinálních gangliích neasociovaných s poškozeným periferním nervem

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

SOLÁR, Peter, Alemeh ZAMANI, Klaudia LAKATOSOVÁ and Marek JOUKAL. The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments. FLUIDS AND BARRIERS OF THE CNS. LONDON: BMC, 2022, vol. 19, No 1, p. 1-79. ISSN 2045-8118. Available from: https://dx.doi.org/10.1186/s12987-022-00312-4.

@article{1861457,
   author = {Solár, Peter and Zamani, Alemeh and Lakatosová, Klaudia and Joukal, Marek},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s12987-022-00312-4},
   keywords = {Subarachnoid hemorrhage; Blood-brain barrier; Subarachnoid hemorrhage treatment; Neuronal injury; Neurovascular unit; Neuroinflammation},
   language = {eng},
   issn = {2045-8118},
   journal = {FLUIDS AND BARRIERS OF THE CNS},
   title = {The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments},
   url = {http://dx.doi.org/10.1186/s12987-022-00312-4},
   volume = {19},
   year = {2022}
}

TY  - JOUR
ID  - 1861457
AU  - Solár, Peter - Zamani, Alemeh - Lakatosová, Klaudia - Joukal, Marek
PY  - 2022
TI  - The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
JF  - FLUIDS AND BARRIERS OF THE CNS
VL  - 19
IS  - 1
SP  - 1-79
EP  - 1-79
PB  - BMC
SN  - 20458118
KW  - Subarachnoid hemorrhage
KW  - Blood-brain barrier
KW  - Subarachnoid hemorrhage treatment
KW  - Neuronal injury
KW  - Neurovascular unit
KW  - Neuroinflammation
UR  - http://dx.doi.org/10.1186/s12987-022-00312-4
N2  - The response of the blood-brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, and astrocytes that affect microglia, neurons, and vascular smooth muscle cells. SAH induces alterations in individual BBB cells, leading to brain homeostasis disruption. Recent experiments have uncovered many pathophysiological cascades affecting the BBB following SAH. Targeting some of these pathways is important for restoring brain function following SAH. BBB injury occurs immediately after SAH and has long-lasting consequences, but most changes in the pathophysiological cascades occur in the first few days following SAH. These changes determine the development of early brain injury as well as delayed cerebral ischemia. SAH-induced neuroprotection also plays an important role and weakens the negative impact of SAH. Supporting some of these beneficial cascades while attenuating the major pathophysiological pathways might be decisive in inhibiting the negative impact of bleeding in the subarachnoid space. In this review, we attempt a comprehensive overview of the current knowledge on the molecular and cellular changes in the BBB following SAH and their possible modulation by various drugs and substances.
ER  -

SOLÁR, Peter, Alemeh ZAMANI, Klaudia LAKATOSOVÁ and Marek JOUKAL. The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments. \textit{FLUIDS AND BARRIERS OF THE CNS}. LONDON: BMC, 2022, vol.~19, No~1, p.~1-79. ISSN~2045-8118. Available from: https://dx.doi.org/10.1186/s12987-022-00312-4.

Detailed Information on Publication Record