Detailed Information on Publication Record
2022
Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects
ANDRŠOVÁ, Irena, Katerina HNATKOVA, Martina ŠIŠÁKOVÁ, Ondřej TOMAN, Peter SMETANA et. al.Basic information
Original name
Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects
Authors
ANDRŠOVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Katerina HNATKOVA (203 Czech Republic), Martina ŠIŠÁKOVÁ (203 Czech Republic, belonging to the institution), Ondřej TOMAN (203 Czech Republic, belonging to the institution), Peter SMETANA, Katharina M HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Georg SCHMIDT and Marek MALÍK (203 Czech Republic, belonging to the institution)
Edition
Frontiers in Physiology, Lausanne, FRONTIERS MEDIA SA, 2022, 1664-042X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.000
RIV identification code
RIV/00216224:14110/22:00126145
Organization unit
Faculty of Medicine
UT WoS
000760998100001
Keywords in English
QT; RR adaptation; RR hysteresis; healthy subjects; non-linear regression modelling; best-fit models; sex differences; age influence
Tags
International impact, Reviewed
Změněno: 17/2/2023 10:08, Mgr. Tereza Miškechová
Abstract
V originále
While it is now well-understood that the extent of QT interval changes due to underlying heart rate differences (i.e., the QT/RR adaptation) needs to be distinguished from the speed with which the QT interval reacts to heart rate changes (i.e., the so-called QT/RR hysteresis), gaps still exist in the physiologic understanding of QT/RR hysteresis processes. This study was designed to address the questions of whether the speed of QT adaptation to heart rate changes is driven by time or by number of cardiac cycles; whether QT interval adaptation speed is the same when heart rate accelerates and decelerates; and whether the characteristics of QT/RR hysteresis are related to age and sex. The study evaluated 897,570 measurements of QT intervals together with their 5-min histories of preceding RR intervals, all recorded in 751 healthy volunteers (336 females) aged 34.3 +/- 9.5 years. Three different QT/RR adaptation models were combined with exponential decay models that distinguished time-based and interval-based QT/RR hysteresis. In each subject and for each modelling combination, a best-fit combination of modelling parameters was obtained by seeking minimal regression residuals. The results showed that the response of QT/RR hysteresis appears to be driven by absolute time rather than by the number of cardiac cycles. The speed of QT/RR hysteresis was found decreasing with increasing age whilst the duration of individually rate corrected QTc interval was found increasing with increasing age. Contrary to the longer QTc intervals, QT/RR hysteresis speed was faster in females. QT/RR hysteresis differences between heart rate acceleration and deceleration were not found to be physiologically systematic (i.e., they differed among different healthy subjects), but on average, QT/RR hysteresis speed was found slower after heart rate acceleration than after rate deceleration.
Links
| MUNI/A/1437/2020, interní kód MU |
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| MUNI/A/1450/2021, interní kód MU |
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