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@article{1863067,
author = {Andršová, Irena and Hnatkova, Katerina and Šišáková, Martina and Toman, Ondřej and Smetana, Peter and Huster, Katharina M and Barthel, Petra and Novotný, Tomáš and Schmidt, Georg and Malík, Marek},
article_location = {Lausanne},
article_number = {February 2022},
doi = {http://dx.doi.org/10.3389/fphys.2021.814542},
keywords = {QT; RR adaptation; RR hysteresis; healthy subjects; non-linear regression modelling; best-fit models; sex differences; age influence},
language = {eng},
issn = {1664-042X},
journal = {Frontiers in Physiology},
title = {Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects},
url = {https://www.frontiersin.org/articles/10.3389/fphys.2021.814542/full},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 1863067
AU - Andršová, Irena - Hnatkova, Katerina - Šišáková, Martina - Toman, Ondřej - Smetana, Peter - Huster, Katharina M - Barthel, Petra - Novotný, Tomáš - Schmidt, Georg - Malík, Marek
PY - 2022
TI - Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects
JF - Frontiers in Physiology
VL - 12
IS - February 2022
SP - 1-25
EP - 1-25
PB - FRONTIERS MEDIA SA
SN - 1664042X
KW - QT
KW - RR adaptation
KW - RR hysteresis
KW - healthy subjects
KW - non-linear regression modelling
KW - best-fit models
KW - sex differences
KW - age influence
UR - https://www.frontiersin.org/articles/10.3389/fphys.2021.814542/full
N2 - While it is now well-understood that the extent of QT interval changes due to underlying heart rate differences (i.e., the QT/RR adaptation) needs to be distinguished from the speed with which the QT interval reacts to heart rate changes (i.e., the so-called QT/RR hysteresis), gaps still exist in the physiologic understanding of QT/RR hysteresis processes. This study was designed to address the questions of whether the speed of QT adaptation to heart rate changes is driven by time or by number of cardiac cycles; whether QT interval adaptation speed is the same when heart rate accelerates and decelerates; and whether the characteristics of QT/RR hysteresis are related to age and sex. The study evaluated 897,570 measurements of QT intervals together with their 5-min histories of preceding RR intervals, all recorded in 751 healthy volunteers (336 females) aged 34.3 +/- 9.5 years. Three different QT/RR adaptation models were combined with exponential decay models that distinguished time-based and interval-based QT/RR hysteresis. In each subject and for each modelling combination, a best-fit combination of modelling parameters was obtained by seeking minimal regression residuals. The results showed that the response of QT/RR hysteresis appears to be driven by absolute time rather than by the number of cardiac cycles. The speed of QT/RR hysteresis was found decreasing with increasing age whilst the duration of individually rate corrected QTc interval was found increasing with increasing age. Contrary to the longer QTc intervals, QT/RR hysteresis speed was faster in females. QT/RR hysteresis differences between heart rate acceleration and deceleration were not found to be physiologically systematic (i.e., they differed among different healthy subjects), but on average, QT/RR hysteresis speed was found slower after heart rate acceleration than after rate deceleration.
ER -
ANDRŠOVÁ, Irena, Katerina HNATKOVA, Martina ŠIŠÁKOVÁ, Ondřej TOMAN, Peter SMETANA, Katharina M HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT and Marek MALÍK. Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects. \textit{Frontiers in Physiology}. Lausanne: FRONTIERS MEDIA SA, 2022, vol.~12, February 2022, p.~1-25. ISSN~1664-042X. Available from: https://dx.doi.org/10.3389/fphys.2021.814542.
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