Detailed Information on Publication Record
2022
Short-Term Beat-to-Beat QT Variability Appears Influenced More Strongly by Recording Quality Than by Beat-to-Beat RR Variability
TOMAN, Ondřej, Katerina HNATKOVA, Martina ŠIŠÁKOVÁ, Peter SMETANA, Katharina M. HUSTER et. al.Basic information
Original name
Short-Term Beat-to-Beat QT Variability Appears Influenced More Strongly by Recording Quality Than by Beat-to-Beat RR Variability
Authors
TOMAN, Ondřej (203 Czech Republic, belonging to the institution), Katerina HNATKOVA (203 Czech Republic), Martina ŠIŠÁKOVÁ (203 Czech Republic, belonging to the institution), Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Irena ANDRŠOVÁ (203 Czech Republic, belonging to the institution), Georg SCHMIDT and Marek MALÍK (203 Czech Republic, belonging to the institution)
Edition
Frontiers in Physiology, Lausanne, FRONTIERS MEDIA SA, 2022, 1664-042X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.000
RIV identification code
RIV/00216224:14110/22:00126157
Organization unit
Faculty of Medicine
UT WoS
000789393200001
Keywords in English
healthy volunteers; long-term ECG; short-term ECG measurements; QT variability; RR variability; ECG noise contents; immediate RR interval effect; regression-based correction
Tags
International impact, Reviewed
Změněno: 28/6/2022 14:21, Mgr. Tereza Miškechová
Abstract
V originále
Increases in beat-to-beat variability of electrocardiographic QT interval duration have repeatedly been associated with increased risk of cardiovascular events and complications. The measurements of QT variability are frequently normalized for the underlying RR interval variability. Such normalization supports the concept of the so-called immediate RR effect which relates each QT interval to the preceding RR interval. The validity of this concept was investigated in the present study together with the analysis of the influence of electrocardiographic morphological stability on QT variability measurements. The analyses involved QT and RR measurements in 6,114,562 individual beats of 642,708 separate 10-s ECG samples recorded in 523 healthy volunteers (259 females). Only beats with high morphology correlation (r > 0.99) with representative waveforms of the 10-s ECG samples were analyzed, assuring that only good quality recordings were included. In addition to these high correlations, SDs of the ECG signal difference between representative waveforms and individual beats expressed morphological instability and ECG noise. In the intra-subject analyses of both individual beats and of 10-s averages, QT interval variability was substantially more strongly related to the ECG noise than to the underlying RR variability. In approximately one-third of the analyzed ECG beats, the prolongation or shortening of the preceding RR interval was followed by the opposite change of the QT interval. In linear regression analyses, underlying RR variability within each 10-s ECG sample explained only 5.7 and 11.1% of QT interval variability in females and males, respectively. On the contrary, the underlying ECG noise contents of the 10-s samples explained 56.5 and 60.1% of the QT interval variability in females and males, respectively. The study concludes that the concept of stable and uniform immediate RR interval effect on the duration of subsequent QT interval duration is highly questionable. Even if only stable beat-to-beat measurements of QT interval are used, the QT interval variability is still substantially influenced by morphological variability and noise pollution of the source ECG recordings. Even when good quality recordings are used, noise contents of the electrocardiograms should be objectively examined in future studies of QT interval variability.
Links
| MUNI/A/1450/2021, interní kód MU |
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