| POLJAK, Michal, Lucie WOHLRABOVA, Eduardo PALAO UTIEL, Jela NOCIAROVÁ, Jiri MISEK, Tomáš SLANINA a Petr KLÁN. Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity. Chemical Communications. Royal Society of Chemistry, 2022, roč. 58, č. 44, s. 6389-6392. ISSN 1359-7345. Dostupné z: https://dx.doi.org/10.1039/d2cc02016e. |
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@article{1863616,
author = {Poljak, Michal and Wohlrabova, Lucie and Palao Utiel, Eduardo and Nociarová, Jela and Misek, Jiri and Slanina, Tomáš and Klán, Petr},
article_number = {44},
doi = {http://dx.doi.org/10.1039/d2cc02016e},
keywords = {FLUORESCENT-PROBES; OXIDATIVE STRESS; HYDROGEN-SULFIDE; SE-BODIPY; CYCLE; SELENOXIDE; PROTEIN; REPAIR; ACID},
language = {eng},
issn = {1359-7345},
journal = {Chemical Communications},
title = {Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity},
url = {https://www.scopus.com/record/display.uri?eid=2-s2.0-85131224229&origin=resultslist&sort=plf-f&src=s&st1=10.1039%2fd2cc02016e&sid=fb45a799d1eb2aeaaeb4725c07aa1af4&sot=b&sdt=b&sl=23&s=DOI%2810.1039%2fd2cc02016e%29&relpos=0&citeCnt=0&searchTerm=&featureTog},
volume = {58},
year = {2022}
}
TY - JOUR
ID - 1863616
AU - Poljak, Michal - Wohlrabova, Lucie - Palao Utiel, Eduardo - Nociarová, Jela - Misek, Jiri - Slanina, Tomáš - Klán, Petr
PY - 2022
TI - Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity
JF - Chemical Communications
VL - 58
IS - 44
SP - 6389-6392
EP - 6389-6392
PB - Royal Society of Chemistry
SN - 13597345
KW - FLUORESCENT-PROBES
KW - OXIDATIVE STRESS
KW - HYDROGEN-SULFIDE
KW - SE-BODIPY
KW - CYCLE
KW - SELENOXIDE
KW - PROTEIN
KW - REPAIR
KW - ACID
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85131224229&origin=resultslist&sort=plf-f&src=s&st1=10.1039%2fd2cc02016e&sid=fb45a799d1eb2aeaaeb4725c07aa1af4&sot=b&sdt=b&sl=23&s=DOI%2810.1039%2fd2cc02016e%29&relpos=0&citeCnt=0&searchTerm=&featureTog
N2 - Many serious diseases are associated with degenerative changes caused by oxidative stress triggered by elevated concentrations of reactive oxygen species (ROS) in cells. Therefore, the development of suitable probes for monitoring such processes is of great importance. Here, we introduce a series of sulfur- and selenium-substituted BODIPY derivatives as reversible redox sensors for ROS and enzymatic redox processes. Significant differences in emission maxima and fluorescence quantum yields between the reduced and oxidized forms make them excellent ratiometric turn-on/off probes. Installation of polar sulfonate groups improved their aqueous solubility while retaining their sensing properties, which allowed the probes to monitor the enzymatic activity of enantioselective methionine sulfoxide reductase.
ER -
POLJAK, Michal, Lucie WOHLRABOVA, Eduardo PALAO UTIEL, Jela NOCIAROVÁ, Jiri MISEK, Tomáš SLANINA a Petr KLÁN. Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity. \textit{Chemical Communications}. Royal Society of Chemistry, 2022, roč.~58, č.~44, s.~6389-6392. ISSN~1359-7345. Dostupné z: https://dx.doi.org/10.1039/d2cc02016e.
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