J 2022

Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

GOMEZ PEREZ, Inmaculada Jennifer, Marina RUSSO, Orazio Angelo ARCIDIACONO, Esther Maria MARQUEZ SANCHEZ - CARNERERO, Petr KLÁN et. al.

Basic information

Original name

Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

Authors

GOMEZ PEREZ, Inmaculada Jennifer (724 Spain, guarantor, belonging to the institution), Marina RUSSO (380 Italy, belonging to the institution), Orazio Angelo ARCIDIACONO (380 Italy, belonging to the institution), Esther Maria MARQUEZ SANCHEZ - CARNERERO (724 Spain, belonging to the institution), Petr KLÁN (203 Czech Republic, belonging to the institution) and Lenka ZAJÍČKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Materials Chemistry Frontiers, Cambridge, Royal Society of Chemistry, 2022, 2052-1537

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10400 1.4 Chemical sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 7.000

RIV identification code

RIV/00216224:14310/22:00126190

Organization unit

Faculty of Science

DOI

UT WoS

000802645400001

Keywords in English

SINGLET OXYGEN GENERATION; PHOTODYNAMIC THERAPY; CARBON DOTS; NANOPARTICLES; DERIVATIVES; MECHANISMS; MOLECULES

Tags

Tags

International impact, Reviewed
Změněno: 3/3/2023 22:45, doc. Mgr. Lenka Zajíčková, Ph.D.

Abstract

V originále

The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation.

Links

EF17_043/0009632, research and development project
Name: CETOCOEN Excellence
EF20_079/0017045, research and development project
Name: MSCAfellow4@MUNI
LM2018121, research and development project
Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI
857560, interní kód MU
(CEP code: EF17_043/0009632)
Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)
Investor: European Union, Spreading excellence and widening participation
90110, large research infrastructures
Name: CzechNanoLab