ASL and 1H MRS in olfactory bulbectomised rats

PAVLOVA, Iveta, Eva DRAŽANOVÁ, Petra AMCHOVÁ, Zenon STARČUK and Jana RUDÁ. ASL and 1H MRS in olfactory bulbectomised rats. In Farmakologické dni 2022. 2022.

Basic information

• Original name: ASL and 1H MRS in olfactory bulbectomised rats
• Name in Czech: ASL a 1H MRS v potkanovi s olfaktornou bulbektómiou
• Authors: PAVLOVA, Iveta, Eva DRAŽANOVÁ, Petra AMCHOVÁ, Zenon STARČUK and Jana RUDÁ.
• Edition: Farmakologické dni 2022, 2022.

Other information

• Original language: English
• Type of outcome: Presentations at conferences
• Field of Study: 10610 Biophysics
• Country of publisher: Slovakia
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Science
• Keywords (in Czech): Arterialne Spinove značenie, depresia, Magnetická Rezonančná Spectroskopia, metabolity, olfaktorná bulbektómia, potkani
• Keywords in English: Arterial Spin Labelling, depression, Magnetic Resonance Spectroscopy, metabolites, olfactory bulbectomy, rats
• Tags: International impact

Abstract

*lateral differences of CBF within both groups may indicate neuronal asymmetry in the THAL region of the SHAM brain and in the smCTX of the OBX brain *differences of metabolite ratios between the groups in the RHIPP may reflect the role of choline in acetylcholine production and release, thus a lower ability of memory storage in OBX rats *lateral difference of mI/tCr indicates its lateral distribution in the hippocampus of the controls *Cho/NAA, NAA/tCr, and Tau/tCr suggest different neuronal activity and density between the left and the right side of the hippocampus of the model group

Abstract (in Czech)

*laterálne rozdiely CBF v rámci oboch skupín môžu naznačovať neuronálnu asymetriu v oblasti THAL mozgu SHAM a v smCTX mozgu OBX *rozdiely v pomeroch metabolitov medzi skupinami v RHIPP môžu odrážať úlohu cholínu pri produkcii a uvoľňovaní acetylcholínu, teda nižšiu schopnosť ukladania pamäte u potkanov OBX *laterálny rozdiel mI/tCr indikuje jeho laterálnu distribúciu v hipokampe kontrol *Cho/NAA, NAA/tCr a Tau/tCr naznačujú rozdielnu neuronálnu aktivitu a hustotu medzi ľavou a pravou stranou hipokampu modelovej skupiny

Links

CZ.02.1.01/0.0/0.0/18_046/00016045, large research infrastructures

• LM2015062, large research infrastructures: Name: National research infrastructure for biological and medical imaging

Investor: Ministry of Education, Youth and Sports of the CR

• LM2015062, large research infrastructures: Name: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministry of Education, Youth and Sports of the CR

• MUNI/A/1440/2021, interní kód MU: Name: Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii (Acronym: Farm-Pre-Klin)

Investor: Masaryk University