In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human ...
HUNAKOVA, L., E. HORVATHOVA, M. MATUSKOVA, Pavel BOBÁĽ, Jan OTEVŘEL and J. BRTKO. In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human breast carcinoma cell lines MCF 7 and MDA-MB-231. Medical Oncology. Cham: Springer Nature, 2022, vol. 39, No 5, p. 1-9. ISSN 1357-0560. Available from: https://dx.doi.org/10.1007/s12032-022-01692-1. |
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Original name | In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human breast carcinoma cell lines MCF 7 and MDA-MB-231 |
Authors | HUNAKOVA, L. (guarantor), E. HORVATHOVA, M. MATUSKOVA, Pavel BOBÁĽ (703 Slovakia, belonging to the institution), Jan OTEVŘEL (203 Czech Republic, belonging to the institution) and J. BRTKO. |
Edition | Medical Oncology, Cham, Springer Nature, 2022, 1357-0560. |
Other information | |
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Original language | English |
Type of outcome | Article in a journal |
Field of Study | 30104 Pharmacology and pharmacy |
Country of publisher | Switzerland |
Confidentiality degree | is not subject to a state or trade secret |
WWW | URL |
Impact factor | Impact factor: 3.400 |
RIV identification code | RIV/00216224:14160/22:00126243 |
Organization unit | Faculty of Pharmacy |
Doi | http://dx.doi.org/10.1007/s12032-022-01692-1 |
UT WoS | 000798611700006 |
Keywords in English | Apoptosis; Breast cancer; Cytotoxicity; DNA crosslinks; Migration; Triorganotin isoselenocyanates |
Tags | rivok, ÚChL |
Tags | International impact, Reviewed |
Changed by | Changed by: JUDr. Sabina Krejčiříková, učo 383857. Changed: 13/7/2022 09:37. |
Abstract |
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Intensive investigation for novel antiproliferative and cytotoxic effective chemical compounds is currently concentrated on structurally modified agents of natural or synthetic source. The selenium derivative of triorganotin compound, triphenyltin isoselenocyanate (TPT-NCSe) caused higher cytotoxicity in hormone sensitive MCF 7 (IC 50-250 nM) in comparison with triple-negative MDA-MB-231 breast carcinoma cell line (IC 50-450 nM) as determined by MTT assay. Measurement of DNA damage showed presence of crosslinks in both cell lines treated by increasing TPT-NCSe concentrations. This compound decreased mitochondrial membrane potential shown by JC-1 staining in a concentration-dependent manner in both cell lines. Activation of caspases-3/7 was observed in MDA-MB-231 cells and was significant only by concentrations causing significant level of crosslinks. On the other hand, migration assay revealed inhibitory effect of viability keeping 100 nM concentration of TPT-NCSe on migration of MDA-MB-231 cells. Our data has shown that this selenium containing triorganotin molecule exerts DNA damage-linked antineoplastic activity in breast carcinoma cell lines studied. |
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MUNI/A/1682/2020, interní kód MU | Name: Návrh, syntéza a hodnocení derivátů skupin léčiv s inhibiční enzymatickou aktivitou |
Investor: Masaryk University |
PrintDisplayed: 12/10/2024 08:51