| HUNAKOVA, L., E. HORVATHOVA, M. MATUSKOVA, Pavel BOBÁĽ, Jan OTEVŘEL and J. BRTKO. In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human breast carcinoma cell lines MCF 7 and MDA-MB-231. Medical Oncology. Cham: Springer Nature, 2022, vol. 39, No 5, p. 1-9. ISSN 1357-0560. Available from: https://dx.doi.org/10.1007/s12032-022-01692-1. |
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@article{1874506,
author = {Hunakova, L. and Horvathova, E. and Matuskova, M. and Bobáľ, Pavel and Otevřel, Jan and Brtko, J.},
article_location = {Cham},
article_number = {5},
doi = {http://dx.doi.org/10.1007/s12032-022-01692-1},
keywords = {Apoptosis; Breast cancer; Cytotoxicity; DNA crosslinks; Migration; Triorganotin isoselenocyanates},
language = {eng},
issn = {1357-0560},
journal = {Medical Oncology},
title = {In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human breast carcinoma cell lines MCF 7 and MDA-MB-231},
url = {https://link.springer.com/content/pdf/10.1007/s12032-022-01692-1.pdf},
volume = {39},
year = {2022}
}
TY - JOUR
ID - 1874506
AU - Hunakova, L. - Horvathova, E. - Matuskova, M. - Bobáľ, Pavel - Otevřel, Jan - Brtko, J.
PY - 2022
TI - In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human breast carcinoma cell lines MCF 7 and MDA-MB-231
JF - Medical Oncology
VL - 39
IS - 5
SP - 1-9
EP - 1-9
PB - Springer Nature
SN - 13570560
KW - Apoptosis
KW - Breast cancer
KW - Cytotoxicity
KW - DNA crosslinks
KW - Migration
KW - Triorganotin isoselenocyanates
UR - https://link.springer.com/content/pdf/10.1007/s12032-022-01692-1.pdf
N2 - Intensive investigation for novel antiproliferative and cytotoxic effective chemical compounds is currently concentrated on structurally modified agents of natural or synthetic source. The selenium derivative of triorganotin compound, triphenyltin isoselenocyanate (TPT-NCSe) caused higher cytotoxicity in hormone sensitive MCF 7 (IC 50-250 nM) in comparison with triple-negative MDA-MB-231 breast carcinoma cell line (IC 50-450 nM) as determined by MTT assay. Measurement of DNA damage showed presence of crosslinks in both cell lines treated by increasing TPT-NCSe concentrations. This compound decreased mitochondrial membrane potential shown by JC-1 staining in a concentration-dependent manner in both cell lines. Activation of caspases-3/7 was observed in MDA-MB-231 cells and was significant only by concentrations causing significant level of crosslinks. On the other hand, migration assay revealed inhibitory effect of viability keeping 100 nM concentration of TPT-NCSe on migration of MDA-MB-231 cells. Our data has shown that this selenium containing triorganotin molecule exerts DNA damage-linked antineoplastic activity in breast carcinoma cell lines studied.
ER -
HUNAKOVA, L., E. HORVATHOVA, M. MATUSKOVA, Pavel BOBÁĽ, Jan OTEVŘEL and J. BRTKO. In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human breast carcinoma cell lines MCF 7 and MDA-MB-231. \textit{Medical Oncology}. Cham: Springer Nature, 2022, vol.~39, No~5, p.~1-9. ISSN~1357-0560. Available from: https://dx.doi.org/10.1007/s12032-022-01692-1.
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