Blood urea nitrogen-independent marker of mortality in sepsis

J 2023

Blood urea nitrogen-independent marker of mortality in sepsis

HARAZIM, Martin, Kaiquan TAN, Marek NALOS and Martin MATĚJOVIČ

Basic information

Original name

Blood urea nitrogen-independent marker of mortality in sepsis

Authors

HARAZIM, Martin (203 Czech Republic, guarantor, belonging to the institution), Kaiquan TAN, Marek NALOS (203 Czech Republic) and Martin MATĚJOVIČ (203 Czech Republic)

Edition

BIOMEDICAL PAPERS-OLOMOUC, OLOMOUC, PALACKY UNIV, MEDICAL FACCENTRAL LIBRARY, 2023, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30221 Critical care medicine and Emergency medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.900 in 2022

RIV identification code

RIV/00216224:14110/23:00129989

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5507/bp.2022.015

UT WoS

000783230000001

Keywords in English

BUN; mortality; sepsis; big data; urea

Abstract

V originále

Background.This retrospective study examines the relationship between admission Blood Urea Nitrogen (BUN) levels and clinical outcomes in patients with sepsis from two separate cohorts in the Czech Republic and the United States. Methods. The study included 9126 patients with sepsis between January 2014 and December 2018. Kaplan-Meier survival curves and Cox regression were used to analyse the data. An optimal cut-off was calculated by means of the Youden-Index. Results. BUN at ICU admission was categorized as 10-20, 20-40 and >40 mg/dL. Comparing the group with the high-est BUN levels to the one with lowest levels, we found HR for 28 days mortality 2.764 (CI 95% 2.37-3.20; P<0.001). We derived an optimal cut-off for prediction of 28 days mortality of 23 mg/dL. The association between BUN and 28 days mortality remained significant after adjusting for potential confounders - for APACHE IV (HR 1.374; 95%CI 1.20-1.58; P<0.001), SAPS2 (HR 1.545; 95%CI 1.35-1.77; P<0.001), eGFR (HR 1.851; 95%CI 1.59-2.16; P<0.001) and several other variables in an integrative model. Conclusions. Our findings support the BUN level as an independent and easily available predictor of 28 days mortality in septic critically ill patients admitted to an ICU.

Citovat

HARAZIM, Martin, Kaiquan TAN, Marek NALOS and Martin MATĚJOVIČ. Blood urea nitrogen-independent marker of mortality in sepsis. BIOMEDICAL PAPERS-OLOMOUC. OLOMOUC: PALACKY UNIV, MEDICAL FACCENTRAL LIBRARY, 2023, vol. 167, No 1, p. 24-29. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2022.015.

@article{1874757,
   author = {Harazim, Martin and Tan, Kaiquan and Nalos, Marek and Matějovič, Martin},
   article_location = {OLOMOUC},
   article_number = {1},
   doi = {http://dx.doi.org/10.5507/bp.2022.015},
   keywords = {BUN; mortality; sepsis; big data; urea},
   language = {eng},
   issn = {1213-8118},
   journal = {BIOMEDICAL PAPERS-OLOMOUC},
   title = {Blood urea nitrogen-independent marker of mortality in sepsis},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3187},
   volume = {167},
   year = {2023}
}

TY  - JOUR
ID  - 1874757
AU  - Harazim, Martin - Tan, Kaiquan - Nalos, Marek - Matějovič, Martin
PY  - 2023
TI  - Blood urea nitrogen-independent marker of mortality in sepsis
JF  - BIOMEDICAL PAPERS-OLOMOUC
VL  - 167
IS  - 1
SP  - 24-29
EP  - 24-29
PB  - PALACKY UNIV, MEDICAL FACCENTRAL LIBRARY
SN  - 12138118
KW  - BUN
KW  - mortality
KW  - sepsis
KW  - big data
KW  - urea
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3187
N2  - Background.This retrospective study examines the relationship between admission Blood Urea Nitrogen (BUN) levels and clinical outcomes in patients with sepsis from two separate cohorts in the Czech Republic and the United States. Methods. The study included 9126 patients with sepsis between January 2014 and December 2018. Kaplan-Meier survival curves and Cox regression were used to analyse the data. An optimal cut-off was calculated by means of the Youden-Index. Results. BUN at ICU admission was categorized as 10-20, 20-40 and >40 mg/dL. Comparing the group with the high-est BUN levels to the one with lowest levels, we found HR for 28 days mortality 2.764 (CI 95% 2.37-3.20; P<0.001). We derived an optimal cut-off for prediction of 28 days mortality of 23 mg/dL. The association between BUN and 28 days mortality remained significant after adjusting for potential confounders - for APACHE IV (HR 1.374; 95%CI 1.20-1.58; P<0.001), SAPS2 (HR 1.545; 95%CI 1.35-1.77; P<0.001), eGFR (HR 1.851; 95%CI 1.59-2.16; P<0.001) and several other variables in an integrative model. Conclusions. Our findings support the BUN level as an independent and easily available predictor of 28 days mortality in septic critically ill patients admitted to an ICU.
ER  -

HARAZIM, Martin, Kaiquan TAN, Marek NALOS and Martin MATĚJOVIČ. Blood urea nitrogen-independent marker of mortality in sepsis. \textit{BIOMEDICAL PAPERS-OLOMOUC}. OLOMOUC: PALACKY UNIV, MEDICAL FACCENTRAL LIBRARY, 2023, vol.~167, No~1, p.~24-29. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2022.015.

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