Detailed Information on Publication Record
2022
Parenteral depot dosage forms in psychiatry and the development of a new particulate dosage form of mirtazapine
KOTOLOVÁ, Hana, Jan JUŘICA, Tomáš HAMMER, Ondřej ZENDULKA, Martina NOVÁKOVÁ et. al.Basic information
Original name
Parenteral depot dosage forms in psychiatry and the development of a new particulate dosage form of mirtazapine
Name in Czech
Parenterální depotní lékové formy v psychiatrii a vývoj nové částicové lékové formy mirtazapinu
Name (in English)
Parenteral depot dosage forms in psychiatry and the development of a new particulate dosage form of mirtazapine
Authors
KOTOLOVÁ, Hana (203 Czech Republic, belonging to the institution), Jan JUŘICA (203 Czech Republic, belonging to the institution), Tomáš HAMMER (203 Czech Republic, belonging to the institution), Ondřej ZENDULKA (203 Czech Republic, belonging to the institution), Martina NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Pavla KAREŠOVÁ, Kateřina KUBOVÁ (203 Czech Republic, belonging to the institution) and Jakub VYSLOUŽIL (203 Czech Republic, belonging to the institution)
Edition
70th Czech-Slovak Pharmacological Days, 2022
Other information
Language
Czech
Type of outcome
Konferenční abstrakt
Field of Study
30104 Pharmacology and pharmacy
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14160/22:00126273
Organization unit
Faculty of Pharmacy
ISSN
Keywords (in Czech)
depotní lékové formy; mirtazapin; neuropsychiatrické onemocnění; nonadherence
Keywords in English
depot dosage forms; mirtazapine; neuropsychiatric illness; nonadherence
Tags
International impact
Změněno: 31/1/2023 15:18, JUDr. Sabina Krejčiříková
V originále
The main advantages of depot psychotropic drugs include improved adherence to treatment, absence of problems with absorption from the gastrointestinal tract, circumvention of first-pass metabolism and absence of risk of accidental or intentional overdose. The development of depot dosage forms is currently focused on the study of microparticles. The drug content, morphology and dissolution test were evaluated for the prepared microparticles containing mirtazapine. The pharmacokinetic profile of administered microparticles was determined based on frequent sampling. The serum was further used to determine liver tests, the lipid spectrum and selected adipokines.
In English
The main advantages of depot psychotropic drugs include improved adherence to treatment, absence of problems with absorption from the gastrointestinal tract, circumvention of first-pass metabolism and absence of risk of accidental or intentional overdose. The development of depot dosage forms is currently focused on the study of microparticles. The drug content, morphology and dissolution test were evaluated for the prepared microparticles containing mirtazapine. The pharmacokinetic profile of administered microparticles was determined based on frequent sampling. The serum was further used to determine liver tests, the lipid spectrum and selected adipokines.
Links
| MUNI/A/1309/2021, interní kód MU |
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| MUNI/A/1440/2021, interní kód MU |
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