Impact of Phosphorylation for Tau210-240 Peptide and Interaction of Small Molecules and 14-3-3ζ Protein Studies Using Computational Methods

BERA, Krishnendu and Jozef HRITZ. Impact of Phosphorylation for Tau210-240 Peptide and Interaction of Small Molecules and 14-3-3ζ Protein Studies Using Computational Methods. In CEITEC PhD Conference. 2022.

Basic information

• Original name: Impact of Phosphorylation for Tau210-240 Peptide and Interaction of Small Molecules and 14-3-3ζ Protein Studies Using Computational Methods
• Authors: BERA, Krishnendu (356 India, belonging to the institution) and Jozef HRITZ (703 Slovakia, belonging to the institution).
• Edition: CEITEC PhD Conference, 2022.

Other information

• Original language: English
• Type of outcome: Presentations at conferences
• Field of Study: 10608 Biochemistry and molecular biology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14740/22:00126277
• Organization unit: Central European Institute of Technology
• Keywords in English: Phosphorylation; Tau210-240 Peptide
• Tags: rivok

Abstract

The conformational dynamics of intrinsically disordered proteins (IDPs) regulated by post-translational modifications such as phosphorylation is challenging to elucidate. A well-known IDP Tau is found hyper-phosphorylated in Alzheimer’s disease (AD) in humans [1]. The proline-rich motif of Tau210-240 peptide directly interacts with proteins such as 14-3-3ζ. 14-3-3ζ is one of the crucial protein in the human brain and bind to a multiarray of proteins. It has a significant impact on forming and deforming neurofibrillary tangles, and it was shown that the 14-3-3ζ monomer has strong anti-aggregation properties [2]. It was shown that monomerization of 14-3-3z can be induced by phosphorylation of Ser58 at the dimeric interface

Links

• GF20-05789L, research and development project: Name: Charakterizace přirozeně neuspořádaných proteinů

Investor: Czech Science Foundation

• LM2018140, research and development project: Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)

Investor: Ministry of Education, Youth and Sports of the CR

• LTAUSA18168, research and development project: Name: Selektivní NMR značení jako nástroj pro charakterizaci proteinových komplexů zapojených do neurodegenerativních onemocnění

Investor: Ministry of Education, Youth and Sports of the CR, Selective NMR labelling as a tool for characterization of protein complexes involved in neurodegenerative diseases., INTER-ACTION