STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC
NANOPARTICLES ON DAFNIA MAGNA

D 2021

STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA

HAVELKOVA, Barbora, Karel SEHNAL, Dominik BANÁŠ, Marta KEPINSKA, Branislav RUTTKAY-NEDECKÝ et. al.

Basic information

Original name

STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA

Authors

HAVELKOVA, Barbora, Karel SEHNAL (203 Czech Republic, belonging to the institution), Dominik BANÁŠ (703 Slovakia, belonging to the institution), Marta KEPINSKA, Branislav RUTTKAY-NEDECKÝ (203 Czech Republic, belonging to the institution), Martina STANKOVA, Carlos FERNANDEZ, Miroslava BEKLOVA and René KIZEK (203 Czech Republic)

Edition

Ostrava, Proceedings 12th International Conference on Nanomaterials - Research & Application, p. 318-323, 6 pp. 2021

Publisher

TANGER LTD

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL

RIV identification code

RIV/00216224:14160/21:00129821

Organization unit

Faculty of Pharmacy

ISBN

978-80-87294-98-7

ISSN

DOI

http://dx.doi.org/10.37904/nanocon.2020.3747

UT WoS

000664505500054

Keywords in English

Ecotoxicology; chemical and biochemical analysis; nanomedicine

Abstract

V originále

Drugs are important xenobiotics in the environment. Their use increases with the growth of the human population, but also in agricultural primary production. Paracetamol (PAR) is a widely used analgesic and antipyretic and its production is still growing. Commonly available drug production technologies are being developed very intensively with nanotechnological modifications for their gradual and targeted release. Nanoparticles (ST/PAR) from starch were prepared: PAR (0, 1, 2, 3, 5 and 10 mg/L) was mixed with citric acid ester in a 1:8 v/v ratio for 30 min at 25 degrees C. By the centrifugation (16.000 g, 30 min) ST/PAR were obtained in the pellet. The effect of PAR was studied on Daphnia magna Straus (Cladocera, Crustacea). Adult females (70-400 mg) were used for self-evaluation. The EC50 was 3.749 mg/L after 48 h of PAR treatment. Total protein values determined by Lowry method were between 0.5-2.2 mg/mL and by Bradford method between 190-676 mg/L. Antioxidant activity values determined by CUPRAC method were between 4-15 mu g/mL GAE and by ABTS method ranged between 40-103 mu g/mL GAE. PAR values were between 9-40 mu M. Subsequently, the biological activity of the prepared nanoparticles was tested.

Citovat

HAVELKOVA, Barbora, Karel SEHNAL, Dominik BANÁŠ, Marta KEPINSKA, Branislav RUTTKAY-NEDECKÝ, Martina STANKOVA, Carlos FERNANDEZ, Miroslava BEKLOVA and René KIZEK. STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA. In Proceedings 12th International Conference on Nanomaterials - Research & Application. Ostrava: TANGER LTD, 2021, p. 318-323. ISBN 978-80-87294-98-7. Available from: https://dx.doi.org/10.37904/nanocon.2020.3747.

@inproceedings{1875857,
   author = {Havelkova, Barbora and Sehnal, Karel and Banáš, Dominik and Kepinska, Marta and RuttkayandNedecký, Branislav and Stankova, Martina and Fernandez, Carlos and Beklova, Miroslava and Kizek, René},
   address = {Ostrava},
   booktitle = {Proceedings 12th International Conference on Nanomaterials - Research & Application},
   doi = {http://dx.doi.org/10.37904/nanocon.2020.3747},
   keywords = {Ecotoxicology; chemical and biochemical analysis; nanomedicine},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Ostrava},
   isbn = {978-80-87294-98-7},
   pages = {318-323},
   publisher = {TANGER LTD},
   title = {STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA},
   url = {https://www.confer.cz/nanocon/2020/3747-study-of-the-effect-of-paracetamol-binded-in-polymeric-nanoparticles-on-dafnia-magna},
   year = {2021}
}

TY  - JOUR
ID  - 1875857
AU  - Havelkova, Barbora - Sehnal, Karel - Banáš, Dominik - Kepinska, Marta - Ruttkay-Nedecký, Branislav - Stankova, Martina - Fernandez, Carlos - Beklova, Miroslava - Kizek, René
PY  - 2021
TI  - STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA
PB  - TANGER LTD
CY  - Ostrava
SN  - 9788087294987
KW  - Ecotoxicology
KW  - chemical and biochemical analysis
KW  - nanomedicine
UR  - https://www.confer.cz/nanocon/2020/3747-study-of-the-effect-of-paracetamol-binded-in-polymeric-nanoparticles-on-dafnia-magna
N2  - Drugs are important xenobiotics in the environment. Their use increases with the growth of the human population, but also in agricultural primary production. Paracetamol (PAR) is a widely used analgesic and antipyretic and its production is still growing. Commonly available drug production technologies are being developed very intensively with nanotechnological modifications for their gradual and targeted release. Nanoparticles (ST/PAR) from starch were prepared: PAR (0, 1, 2, 3, 5 and 10 mg/L) was mixed with citric acid ester in a 1:8 v/v ratio for 30 min at 25 degrees C. By the centrifugation (16.000 g, 30 min) ST/PAR were obtained in the pellet. The effect of PAR was studied on Daphnia magna Straus (Cladocera, Crustacea). Adult females (70-400 mg) were used for self-evaluation. The EC50 was 3.749 mg/L after 48 h of PAR treatment. Total protein values determined by Lowry method were between 0.5-2.2 mg/mL and by Bradford method between 190-676 mg/L. Antioxidant activity values determined by CUPRAC method were between 4-15 mu g/mL GAE and by ABTS method ranged between 40-103 mu g/mL GAE. PAR values were between 9-40 mu M. Subsequently, the biological activity of the prepared nanoparticles was tested.
ER  -

HAVELKOVA, Barbora, Karel SEHNAL, Dominik BANÁŠ, Marta KEPINSKA, Branislav RUTTKAY-NEDECKÝ, Martina STANKOVA, Carlos FERNANDEZ, Miroslava BEKLOVA and René KIZEK. STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA. In \textit{Proceedings 12th International Conference on Nanomaterials - Research \&{} Application}. Ostrava: TANGER LTD, 2021, p.~318-323. ISBN~978-80-87294-98-7. Available from: https://dx.doi.org/10.37904/nanocon.2020.3747.

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