HAVELKOVA, Barbora, Karel SEHNAL, Dominik BANÁŠ, Marta KEPINSKA, Branislav RUTTKAY-NEDECKÝ, Martina STANKOVA, Carlos FERNANDEZ, Miroslava BEKLOVA and René KIZEK. STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA. In Proceedings 12th International Conference on Nanomaterials - Research & Application. Ostrava: TANGER LTD, 2021, p. 318-323. ISBN 978-80-87294-98-7. Available from: https://dx.doi.org/10.37904/nanocon.2020.3747.
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Basic information
Original name STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA
Authors HAVELKOVA, Barbora, Karel SEHNAL (203 Czech Republic, belonging to the institution), Dominik BANÁŠ (703 Slovakia, belonging to the institution), Marta KEPINSKA, Branislav RUTTKAY-NEDECKÝ (203 Czech Republic, belonging to the institution), Martina STANKOVA, Carlos FERNANDEZ, Miroslava BEKLOVA and René KIZEK (203 Czech Republic).
Edition Ostrava, Proceedings 12th International Conference on Nanomaterials - Research & Application, p. 318-323, 6 pp. 2021.
Publisher TANGER LTD
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
WWW URL
RIV identification code RIV/00216224:14160/21:00129821
Organization unit Faculty of Pharmacy
ISBN 978-80-87294-98-7
ISSN 2694-930X
Doi http://dx.doi.org/10.37904/nanocon.2020.3747
UT WoS 000664505500054
Keywords in English Ecotoxicology; chemical and biochemical analysis; nanomedicine
Tags rivok, ÚMF
Changed by Changed by: JUDr. Sabina Krejčiříková, učo 383857. Changed: 3/8/2023 10:41.
Abstract
Drugs are important xenobiotics in the environment. Their use increases with the growth of the human population, but also in agricultural primary production. Paracetamol (PAR) is a widely used analgesic and antipyretic and its production is still growing. Commonly available drug production technologies are being developed very intensively with nanotechnological modifications for their gradual and targeted release. Nanoparticles (ST/PAR) from starch were prepared: PAR (0, 1, 2, 3, 5 and 10 mg/L) was mixed with citric acid ester in a 1:8 v/v ratio for 30 min at 25 degrees C. By the centrifugation (16.000 g, 30 min) ST/PAR were obtained in the pellet. The effect of PAR was studied on Daphnia magna Straus (Cladocera, Crustacea). Adult females (70-400 mg) were used for self-evaluation. The EC50 was 3.749 mg/L after 48 h of PAR treatment. Total protein values determined by Lowry method were between 0.5-2.2 mg/mL and by Bradford method between 190-676 mg/L. Antioxidant activity values determined by CUPRAC method were between 4-15 mu g/mL GAE and by ABTS method ranged between 40-103 mu g/mL GAE. PAR values were between 9-40 mu M. Subsequently, the biological activity of the prepared nanoparticles was tested.
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