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@article{1876015,
author = {Berec, Luděk and Šmíd, Martin and Přibylová, Lenka and Májek, Ondřej and Pavlík, Tomáš and Jarkovský, Jiří and Zajíček, Milan and Weiner, Jakub and Barusová, Tamara and Trnka, Jan},
article_number = {7},
doi = {http://dx.doi.org/10.1371/journal.pone.0270801},
keywords = {COVID 19; SARS CoV 2; Viral vaccines; Vaccines; Czech Republic; Immunity; Vaccination and immunization; Booster doses},
language = {eng},
issn = {1932-6203},
journal = {PLoS ONE},
title = {Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia},
url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270801},
volume = {17},
year = {2022}
}
TY - JOUR
ID - 1876015
AU - Berec, Luděk - Šmíd, Martin - Přibylová, Lenka - Májek, Ondřej - Pavlík, Tomáš - Jarkovský, Jiří - Zajíček, Milan - Weiner, Jakub - Barusová, Tamara - Trnka, Jan
PY - 2022
TI - Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia
JF - PLoS ONE
VL - 17
IS - 7
SP - 1-13
EP - 1-13
PB - Public Library of Science
SN - 19326203
KW - COVID 19
KW - SARS CoV 2
KW - Viral vaccines
KW - Vaccines
KW - Czech Republic
KW - Immunity
KW - Vaccination and immunization
KW - Booster doses
UR - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270801
N2 - Studies demonstrating the waning of post-vaccination and post-infection immunity against covid-19 generally analyzed a limited range of vaccines or subsets of populations. Using Czech national health data from the beginning of the covid-19 pandemic till November 20, 2021 we estimated the risks of reinfection, breakthrough infection, hospitalization and death by a Cox regression adjusted for sex, age, vaccine type and vaccination status. Vaccine effectiveness against infection declined from 87% at 0-2 months after the second dose to 53% at 7-8 months for BNT162b2 vaccine, from 90% at 0-2 months to 65% at 7-8 months for mRNA-1273, and from 83% at 0-2 months to 55% at 5-6 months for the ChAdOx1-S. Effectiveness against hospitalization and deaths declined by about 15% and 10%, respectively, during the first 6-8 months. Boosters (third dose) returned the protection to the levels observed shortly after dose 2. In unvaccinated, previously infected individuals the protection against infection declined from 97% after 2 months to 72% at 18 months. Our results confirm the waning of vaccination-induced immunity against infection and a smaller decline in the protection against hospitalization and death. Boosting restores the original vaccine effectiveness. Post-infection immunity also decreases over time.
ER -
BEREC, Luděk, Martin ŠMÍD, Lenka PŘIBYLOVÁ, Ondřej MÁJEK, Tomáš PAVLÍK, Jiří JARKOVSKÝ, Milan ZAJÍČEK, Jakub WEINER, Tamara BARUSOVÁ and Jan TRNKA. Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia. \textit{PLoS ONE}. Public Library of Science, 2022, vol.~17, No~7, p.~1-13. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0270801.
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