Other formats:
BibTeX
LaTeX
RIS
@article{1876276, author = {Salát, Jiří and Straková, Petra and Růžek, Daniel}, article_number = {7}, doi = {http://dx.doi.org/10.3390/vaccines10071001}, keywords = {tick-borne encephalitis virus; vaccine; non-structural protein 1}, language = {eng}, issn = {2076-393X}, journal = {Vaccines}, title = {Dynamics of Whole Virus and Non-Structural Protein 1 (NS1) IgG Response in Mice Immunized with Two Commercial Tick-Borne Encephalitis Vaccines.}, url = {https://www.mdpi.com/2076-393X/10/7/1001}, volume = {10}, year = {2022} }
TY - JOUR ID - 1876276 AU - Salát, Jiří - Straková, Petra - Růžek, Daniel PY - 2022 TI - Dynamics of Whole Virus and Non-Structural Protein 1 (NS1) IgG Response in Mice Immunized with Two Commercial Tick-Borne Encephalitis Vaccines. JF - Vaccines VL - 10 IS - 7 SP - 1-6 EP - 1-6 PB - MDPI SN - 2076393X KW - tick-borne encephalitis virus KW - vaccine KW - non-structural protein 1 UR - https://www.mdpi.com/2076-393X/10/7/1001 N2 - The presence of a non-structural protein 1 (NS1) in tick-borne encephalitis (TBE) vaccines and the possible induction of an NS1-specific immune response in vaccinated individuals remains a somewhat controversial topic. Previously, we detected the presence of NS1 in the Encepur TBE vaccine by mass spectrometry and found the induction of NS1-specific IgG antibodies in mice vaccinated with the FSME-Immun TBE vaccine. Here, in this follow-up study, we examined the dynamics and extent of the NS1-specific IgG response in mice vaccinated with these two vaccines in more detail and compared it with the IgG response to the whole virus (WV). Mice were vaccinated at two-week intervals with a total of six doses of each vaccine, and levels of IgG antibodies to TBE virus WV and NS1 were measured by ELISA after each dose. Both vaccines elicited a robust anti-WV IgG response after two doses. The Encepur vaccine did not elicit NS1-specific IgG even after all six doses. In contrast, the FSME-Immun vaccine triggered the production of NS1-specific IgG after four doses. The results indicate that FSME-Immun is the only vaccine that elicits an NS1-specific antibody response in mice. However, compared to WV-specific IgG, the NS1-specific response is weaker, and a higher number of doses is required to induce detectable levels of NS1-specific IgG antibodies. ER -
SALÁT, Jiří, Petra STRAKOVÁ and Daniel RŮŽEK. Dynamics of Whole Virus and Non-Structural Protein 1 (NS1) IgG Response in Mice Immunized with Two Commercial Tick-Borne Encephalitis Vaccines. \textit{Vaccines}. MDPI, 2022, vol.~10, No~7, p.~1-6. ISSN~2076-393X. Available from: https://dx.doi.org/10.3390/vaccines10071001.
|