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@article{1882997,
author = {Bosáková, Veronika and De Zuani, Marco and Sládková, Lucie and Garlíková, Zuzana and Sushama Jose, Shyam and Zelante, Teresa and Hortová Kohoutková, Marcela and Frič, Jan},
article_location = {LAUSANNE},
article_number = {July 2022},
doi = {http://dx.doi.org/10.3389/fcell.2022.899368},
keywords = {3D structure; chronic obstructive pulmonary disease; cystic fibrosis - CF; human disease modelling; induced pluripotent stem cells; lung cancer; lung organoids},
language = {eng},
issn = {2296-634X},
journal = {FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY},
title = {Lung Organoids-The Ultimate Tool to Dissect Pulmonary Diseases?},
url = {https://www.frontiersin.org/articles/10.3389/fcell.2022.899368/full},
volume = {10},
year = {2022}
}
TY - JOUR
ID - 1882997
AU - Bosáková, Veronika - De Zuani, Marco - Sládková, Lucie - Garlíková, Zuzana - Sushama Jose, Shyam - Zelante, Teresa - Hortová Kohoutková, Marcela - Frič, Jan
PY - 2022
TI - Lung Organoids-The Ultimate Tool to Dissect Pulmonary Diseases?
JF - FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
VL - 10
IS - July 2022
SP - 1-19
EP - 1-19
PB - FRONTIERS MEDIA SA
SN - 2296634X
KW - 3D structure
KW - chronic obstructive pulmonary disease
KW - cystic fibrosis - CF
KW - human disease modelling
KW - induced pluripotent stem cells
KW - lung cancer
KW - lung organoids
UR - https://www.frontiersin.org/articles/10.3389/fcell.2022.899368/full
N2 - Organoids are complex multicellular three-dimensional (3D) in vitro models that are designed to allow accurate studies of the molecular processes and pathologies of human organs. Organoids can be derived from a variety of cell types, such as human primary progenitor cells, pluripotent stem cells, or tumor-derived cells and can be co-cultured with immune or microbial cells to further mimic the tissue niche. Here, we focus on the development of 3D lung organoids and their use as disease models and drug screening tools. We introduce the various experimental approaches used to model complex human diseases and analyze their advantages and disadvantages. We also discuss validation of the organoids and their physiological relevance to the study of lung diseases. Furthermore, we summarize the current use of lung organoids as models of host-pathogen interactions and human lung diseases such as cystic fibrosis, chronic obstructive pulmonary disease, or SARS-CoV-2 infection. Moreover, we discuss the use of lung organoids derived from tumor cells as lung cancer models and their application in personalized cancer medicine research. Finally, we outline the future of research in the field of human induced pluripotent stem cell-derived organoids.
ER -
BOSÁKOVÁ, Veronika, Marco DE ZUANI, Lucie SLÁDKOVÁ, Zuzana GARLÍKOVÁ, Shyam SUSHAMA JOSE, Teresa ZELANTE, Marcela HORTOVÁ KOHOUTKOVÁ and Jan FRIČ. Lung Organoids-The Ultimate Tool to Dissect Pulmonary Diseases? \textit{FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2022, vol.~10, July 2022, p.~1-19. ISSN~2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2022.899368.
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