Detailed Information on Publication Record
2022
Lung Organoids-The Ultimate Tool to Dissect Pulmonary Diseases?
BOSÁKOVÁ, Veronika, Marco DE ZUANI, Lucie SLÁDKOVÁ, Zuzana GARLÍKOVÁ, Shyam SUSHAMA JOSE et. al.Basic information
Original name
Lung Organoids-The Ultimate Tool to Dissect Pulmonary Diseases?
Authors
BOSÁKOVÁ, Veronika (203 Czech Republic, belonging to the institution), Marco DE ZUANI (380 Italy), Lucie SLÁDKOVÁ (203 Czech Republic), Zuzana GARLÍKOVÁ (203 Czech Republic), Shyam SUSHAMA JOSE (356 India), Teresa ZELANTE (380 Italy), Marcela HORTOVÁ KOHOUTKOVÁ (203 Czech Republic) and Jan FRIČ (203 Czech Republic, guarantor)
Edition
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2022, 2296-634X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10601 Cell biology
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 5.500
RIV identification code
RIV/00216224:14110/22:00126339
Organization unit
Faculty of Medicine
UT WoS
000886940200001
Keywords in English
3D structure; chronic obstructive pulmonary disease; cystic fibrosis - CF; human disease modelling; induced pluripotent stem cells; lung cancer; lung organoids
Tags
International impact, Reviewed
Změněno: 20/2/2023 09:00, Mgr. Tereza Miškechová
Abstract
V originále
Organoids are complex multicellular three-dimensional (3D) in vitro models that are designed to allow accurate studies of the molecular processes and pathologies of human organs. Organoids can be derived from a variety of cell types, such as human primary progenitor cells, pluripotent stem cells, or tumor-derived cells and can be co-cultured with immune or microbial cells to further mimic the tissue niche. Here, we focus on the development of 3D lung organoids and their use as disease models and drug screening tools. We introduce the various experimental approaches used to model complex human diseases and analyze their advantages and disadvantages. We also discuss validation of the organoids and their physiological relevance to the study of lung diseases. Furthermore, we summarize the current use of lung organoids as models of host-pathogen interactions and human lung diseases such as cystic fibrosis, chronic obstructive pulmonary disease, or SARS-CoV-2 infection. Moreover, we discuss the use of lung organoids derived from tumor cells as lung cancer models and their application in personalized cancer medicine research. Finally, we outline the future of research in the field of human induced pluripotent stem cell-derived organoids.
Links
| MUNI/A/1418/2021, interní kód MU |
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