Detailed Information on Publication Record
2022
Development and Comparison of Various Coated Hard Capsules Suitable for Enteric Administration to Small Patient Cohorts
FÜLÖPOVÁ, Nicole, Sylvie PAVLOKOVÁ, DeBono IVAN, David VETCHÝ, Aleš FRANC et. al.Basic information
Original name
Development and Comparison of Various Coated Hard Capsules Suitable for Enteric Administration to Small Patient Cohorts
Authors
FÜLÖPOVÁ, Nicole (703 Slovakia, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution), DeBono IVAN, David VETCHÝ (203 Czech Republic, belonging to the institution) and Aleš FRANC (203 Czech Republic, guarantor, belonging to the institution)
Edition
Pharmaceutics, Basel, MDPI, 2022, 1999-4923
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 5.400
RIV identification code
RIV/00216224:14160/22:00126355
Organization unit
Faculty of Pharmacy
UT WoS
000846546700001
Keywords in English
DRcapsTM capsules; hard gelatin capsules; Eudragit® S; enteric coating; immersion method; principal component analysis
Tags
International impact
Změněno: 31/10/2022 11:19, JUDr. Sabina Krejčiříková
Abstract
V originále
Pharmaceutical technology offers several options for protecting substances from acidic environments, such as encapsulation in enteric capsules or dosage form with enteric coating. However, commercial enteric capsules do not always meet limits for pharmacopeial delayed release, and the coating process is generally challenging. Preparing small enteric batches suitable for clinical use is, therefore, an unsolved problem. This experiment offers a simple coating process of DRcapsTM capsules based on hypromellose (HPMC) and gellan gum to achieve small intestine administration. In addition, DRcapsTM capsules were compared to hard gelatin capsules to evaluate the suitability of the coating method. Both capsules were immersed in dispersions of Eudragit® S 100, Acryl-EZE®, and Cellacefate at concentrations of 10.0, 15.0, and 20.0% and dried. Coated capsules were evaluated by electron microscopy, disintegration, and dissolution test with a two-step pH change (from 1.2 to 6.8, then to 7.5) to simulate passage through the digestive tract. DRcapsTM capsules coated with Eudragit® S and Cellacefate achieved acid resistance. While samples coated with Eudragit® S released their contents within 360 min at pH 6.8 (small intestine), regardless of polymer concentration, capsules with 15.0 and 20.0% coatings of Cellacefate released content at pH 7.5 (colon) within 435 and 495 min, respectively.
Links
| MUNI/A/1574/2020, interní kód MU |
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