Antigen Presentation by Common Variable Immunodeficiency (CVID)
B Cells and Monocytes is Unimpaired

J 1997

Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired

THON, Vojtěch, H. EGGENBAUER, HM. WOLF, MB. FISCHER, J. LITZMAN et. al.

Basic information

Original name

Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired

Name in Czech

Antigenní prezentace B lymfocytů a monocytů není u běžné variabilní imunodeficience (CVID) oslabena

Authors

THON, Vojtěch (203 Czech Republic, guarantor), H. EGGENBAUER (40 Austria), HM. WOLF (40 Austria), MB. FISCHER (40 Austria), J. LITZMAN (203 Czech Republic) and J. LOKAJ (203 Czech Republic)

Edition

Clin.Exp.Immunol. 1997, 0009-9104

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.506

RIV identification code

RIV/00216224:14110/97:00030213

Organization unit

Faculty of Medicine

UT WoS

A1997WR92700001

Keywords (in Czech)

CVID

Keywords in English

common variable immunodeficiency; antigen presentation; B cells; monocytes

Abstract

ORIG CZ

V originále

CVID is a primary immunodeficiency syndrome comprising a heterogeneous group of patients with hypogammaglobulinaemia and defective formation of specific antibodies. Previous studies demonstrated defective T cell responsiveness to antigen in a major subgroup of patients. In the present study we investigated the capacity of peripheral blood monocytes and Epstein-Barr virus (EBV)-transformed B cell lines from seven patients with CVID, including two patients expressing an extended MHC haplotype described to be associated with CVID, to present antigen (Tet. Tox.) to CD4(+) antigen-specific T cell lines from healthy controls. The results presented show an unimpaired capacity of peripheral blood monocytes to present antigen in all patients studied. In addition, the present study demonstrates for the first time that CVID B cells function normally as antigen-presenting cells (APC). These findings indicate that expression of a certain MHC phenotype in CVID is not associated with a defect in the presentation of recall antigen by monocytes and B cells. Based on these studies, uptake, processing and re-expression of recall antigen in association with MHC class II molecules on the APC surface are functional and there is no indication far structural abnormalities of the MHC class II molecules expressed by the patients studied that could be essential for their function in antigen binding and presentation.

In Czech

Antigenní prezentace B lymfocytů a monocytů není u běžné variabilní imunodeficience (CVID) oslabena.

Citovat

THON, Vojtěch, H. EGGENBAUER, HM. WOLF, MB. FISCHER, J. LITZMAN and J. LOKAJ. Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired. Clin.Exp.Immunol. 1997, vol. 31, No 1, p. 1-8. ISSN 0009-9104.

@article{192301,
   author = {Thon, Vojtěch and Eggenbauer, H. and Wolf, HM. and Fischer, MB. and Litzman, J. and Lokaj, J.},
   article_number = {1},
   keywords = {common variable immunodeficiency; antigen presentation; B cells; monocytes},
   language = {eng},
   issn = {0009-9104},
   journal = {Clin.Exp.Immunol.},
   title = {Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired},
   volume = {31},
   year = {1997}
}

TY  - JOUR
ID  - 192301
AU  - Thon, Vojtěch - Eggenbauer, H. - Wolf, HM. - Fischer, MB. - Litzman, J. - Lokaj, J.
PY  - 1997
TI  - Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired
JF  - Clin.Exp.Immunol.
VL  - 31
IS  - 1
SP  - 1
EP  - 1
SN  - 00099104
KW  - common variable immunodeficiency
KW  - antigen presentation
KW  - B cells
KW  - monocytes
N2  - CVID is a primary immunodeficiency syndrome comprising a heterogeneous group of patients with hypogammaglobulinaemia and defective formation of specific antibodies. Previous studies demonstrated defective T cell responsiveness to antigen in a major subgroup of patients. In the present study we investigated the capacity of peripheral blood monocytes and Epstein-Barr virus (EBV)-transformed B cell lines from seven patients with CVID, including two patients expressing an extended MHC haplotype described to be associated with CVID, to present antigen (Tet. Tox.) to CD4(+) antigen-specific T cell lines from healthy controls. The results presented show an unimpaired capacity of peripheral blood monocytes to present antigen in all patients studied. In addition, the present study demonstrates for the first time that CVID B cells function normally as antigen-presenting cells (APC). These findings indicate that expression of a certain MHC phenotype in CVID is not associated with a defect in the presentation of recall antigen by monocytes and B cells. Based on these studies, uptake, processing and re-expression of recall antigen in association with MHC class II molecules on the APC surface are functional and there is no indication far structural abnormalities of the MHC class II molecules expressed by the patients studied that could be essential for their function in antigen binding and presentation.
ER  -

THON, Vojtěch, H. EGGENBAUER, HM. WOLF, MB. FISCHER, J. LITZMAN and J. LOKAJ. Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired. \textit{Clin.Exp.Immunol.}. 1997, vol.~31, No~1, p.~1-8. ISSN~0009-9104.

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