LITZMAN, Jiří, A.M. WARD, G. WILD, Vladimír ZNOJIL a G. MORGAN. Serum IgD Levels in Children under Investigation and with Defined immunodeficiency. Int.Arch.Allerg.Immunol. Basel: Karger AG, roč. 114, č. 1, s. 54-58. ISSN 1018-2438. 1997.
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Základní údaje
Originální název Serum IgD Levels in Children under Investigation and with Defined immunodeficiency
Autoři LITZMAN, Jiří (203 Česká republika, garant), A.M. WARD (826 Velká Británie a Severní Irsko), G. WILD (826 Velká Británie a Severní Irsko), Vladimír ZNOJIL (203 Česká republika) a G. MORGAN (826 Velká Británie a Severní Irsko).
Vydání Int.Arch.Allerg.Immunol. Basel, Karger AG, 1997, 1018-2438.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30102 Immunology
Stát vydavatele Švýcarsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.721
Kód RIV RIV/00216224:14110/97:00030215
Organizační jednotka Lékařská fakulta
UT WoS A1997XR99700008
Klíčová slova anglicky IgD; immunodeficiency; childhood
Štítky childhood, IgD, immunodeficiency
Změnil Změnil: prof. MUDr. Jiří Litzman, CSc., učo 403. Změněno: 22. 6. 2009 16:29.
Anotace
BACKGROUND: The function and regulation of circulating IgD are unclear. Serum IgD levels were increased in a wide range of immunological diseases but these associations did not give a clue to the regulation of serum IgD production. METHODS: Serum IgD levels in 131 children with various non-HIV-related immunodeficiency diseases were investigated to examine their relationship with immunoglobulin or antibody production and activation of the immune system. Data from a group of 109 nonimmunodeficient children were also available for comparison. RESULTS: There was a bimodal distribution of serum IgD levels. In 87 patients IgD levels fell below the limit of detection of 5 IU/ml, while the remainder showed an approximately normal distribution skewed to the right after log transformation. The proportion of children with undetectable IgD levels (< 5 IU/ml) was significantly increased in immunodeficient children (87/131 vs. 28/109, p < 0.001). No difference in the occurrence of immunoglobulin or antibody deficiencies was demonstrated in immunodeficient children with detectable and nondetectable IgD levels. There was a positive correlation of serum IgD with age, serum IgA and IgE, white blood count and CD4+CD25+ lymphocytes but not with other immunoglobulin isotypes or immune activation markers. CONCLUSION: Determination of serum IgD levels did not seem to be of particular clinical benefit in the investigation of HIV-negative immunodeficient children and serum IgD levels were not associated with the general picture of immune activation. Observed distribution patterns and associations may have implications for the regulation of serum IgD production.
Anotace česky
Byla měřena hladina IgD u dětí s podezřením na primární imunodefcit.
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