Serum IgD Levels in Children under Investigation and with
Defined immunodeficiency

J 1997

Serum IgD Levels in Children under Investigation and with Defined immunodeficiency

LITZMAN, Jiří, A.M. WARD, G. WILD, Vladimír ZNOJIL, G. MORGAN et. al.

Basic information

Original name

Serum IgD Levels in Children under Investigation and with Defined immunodeficiency

Authors

LITZMAN, Jiří (203 Czech Republic, guarantor), A.M. WARD (826 United Kingdom of Great Britain and Northern Ireland), G. WILD (826 United Kingdom of Great Britain and Northern Ireland), Vladimír ZNOJIL (203 Czech Republic) and G. MORGAN (826 United Kingdom of Great Britain and Northern Ireland)

Edition

Int.Arch.Allerg.Immunol. Basel, Karger AG, 1997, 1018-2438

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.721

RIV identification code

RIV/00216224:14110/97:00030215

Organization unit

Faculty of Medicine

UT WoS

A1997XR99700008

Keywords in English

IgD; immunodeficiency; childhood

Abstract

ORIG CZ

V originále

BACKGROUND: The function and regulation of circulating IgD are unclear. Serum IgD levels were increased in a wide range of immunological diseases but these associations did not give a clue to the regulation of serum IgD production. METHODS: Serum IgD levels in 131 children with various non-HIV-related immunodeficiency diseases were investigated to examine their relationship with immunoglobulin or antibody production and activation of the immune system. Data from a group of 109 nonimmunodeficient children were also available for comparison. RESULTS: There was a bimodal distribution of serum IgD levels. In 87 patients IgD levels fell below the limit of detection of 5 IU/ml, while the remainder showed an approximately normal distribution skewed to the right after log transformation. The proportion of children with undetectable IgD levels (< 5 IU/ml) was significantly increased in immunodeficient children (87/131 vs. 28/109, p < 0.001). No difference in the occurrence of immunoglobulin or antibody deficiencies was demonstrated in immunodeficient children with detectable and nondetectable IgD levels. There was a positive correlation of serum IgD with age, serum IgA and IgE, white blood count and CD4+CD25+ lymphocytes but not with other immunoglobulin isotypes or immune activation markers. CONCLUSION: Determination of serum IgD levels did not seem to be of particular clinical benefit in the investigation of HIV-negative immunodeficient children and serum IgD levels were not associated with the general picture of immune activation. Observed distribution patterns and associations may have implications for the regulation of serum IgD production.

In Czech

Byla měřena hladina IgD u dětí s podezřením na primární imunodefcit.

Citovat

LITZMAN, Jiří, A.M. WARD, G. WILD, Vladimír ZNOJIL and G. MORGAN. Serum IgD Levels in Children under Investigation and with Defined immunodeficiency. Int.Arch.Allerg.Immunol. Basel: Karger AG, 1997, vol. 114, No 1, p. 54-58. ISSN 1018-2438.

@article{192907,
   author = {Litzman, Jiří and Ward, A.M. and Wild, G. and Znojil, Vladimír and Morgan, G.},
   article_location = {Basel},
   article_number = {1},
   keywords = {IgD; immunodeficiency; childhood},
   language = {eng},
   issn = {1018-2438},
   journal = {Int.Arch.Allerg.Immunol.},
   title = {Serum IgD Levels in Children under Investigation and with Defined immunodeficiency},
   volume = {114},
   year = {1997}
}

TY  - JOUR
ID  - 192907
AU  - Litzman, Jiří - Ward, A.M. - Wild, G. - Znojil, Vladimír - Morgan, G.
PY  - 1997
TI  - Serum IgD Levels in Children under Investigation and with Defined immunodeficiency
JF  - Int.Arch.Allerg.Immunol.
VL  - 114
IS  - 1
SP  - 54
EP  - 54
PB  - Karger AG
SN  - 10182438
KW  - IgD
KW  - immunodeficiency
KW  - childhood
N2  - BACKGROUND: The function and regulation of circulating IgD are unclear. Serum IgD levels were increased in a wide range of immunological diseases but these associations did not give a clue to the regulation of serum IgD production. METHODS: Serum IgD levels in 131 children with various non-HIV-related immunodeficiency diseases were investigated to examine their relationship with immunoglobulin or antibody production and activation of the immune system. Data from a group of 109 nonimmunodeficient children were also available for comparison. RESULTS: There was a bimodal distribution of serum IgD levels. In 87 patients IgD levels fell below the limit of detection of 5 IU/ml, while the remainder showed an approximately normal distribution skewed to the right after log transformation. The proportion of children with undetectable IgD levels (< 5 IU/ml) was significantly increased in immunodeficient children (87/131 vs. 28/109, p < 0.001). No difference in the occurrence of immunoglobulin or antibody deficiencies was demonstrated in immunodeficient children with detectable and nondetectable IgD levels. There was a positive correlation of serum IgD with age, serum IgA and IgE, white blood count and CD4+CD25+ lymphocytes but not with other immunoglobulin isotypes or immune activation markers. CONCLUSION: Determination of serum IgD levels did not seem to be of particular clinical benefit in the investigation of HIV-negative immunodeficient children and serum IgD levels were not associated with the general picture of immune activation. Observed distribution patterns and associations may have implications for the regulation of serum IgD production.
ER  -

LITZMAN, Jiří, A.M. WARD, G. WILD, Vladimír ZNOJIL and G. MORGAN. Serum IgD Levels in Children under Investigation and with Defined immunodeficiency. \textit{Int.Arch.Allerg.Immunol.}. Basel: Karger AG, 1997, vol.~114, No~1, p.~54-58. ISSN~1018-2438.

Detailed Information on Publication Record