J 1999

Association analysis of 24-h blood pressure records with I/D ACE gene polymorphism and AB0 blood group system

VAŠKŮ, Anna, Miroslav SOUČEK, Dobroslav HÁJEK, Lydie HOLLÁ, Vladimír ZNOJIL et. al.

Basic information

Original name

Association analysis of 24-h blood pressure records with I/D ACE gene polymorphism and AB0 blood group system

Authors

VAŠKŮ, Anna (203 Czech Republic, guarantor), Miroslav SOUČEK (203 Czech Republic), Dobroslav HÁJEK (203 Czech Republic), Lydie HOLLÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)

Edition

Physiological Research, 1999, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.521

RIV identification code

RIV/00216224:14110/99:00000716

Organization unit

Faculty of Medicine

UT WoS

000080227700002

Keywords in English

circadian blood pressure rhythm; I/D ACE polymorphism; ABO blood group system; sex; body mass index
Změněno: 17/6/2009 13:17, prof. MUDr. Lydie Izakovičová Hollá, Ph.D.

Abstract

V originále

The purpose of the study was to analyse associations among 24-h blood pressure records parameters, insertion/deletion angiotensin I converting enzyme gene polymorphism and ABO blood group system in sample of Czech subjects from general population. Eleven parameters describing the 24-h blood pressure readings were obtained from the analysis of the 24-h blood pressure records in 243 volunteers, 119 men and 124 women. Using multivariation analysis of variance, the parameters were adjusted for sex and BMI. All the subjects were genotyped for insertion/deletion angiotensin I converting enzyme (I/D ACE) gene polymorphism. They were examined for the blood group in ABO system routinely. An association between interaction of I/D ACE gene polymorphism and ABO blood group systém on the one side and mean values of systolic (p=0.016), mean arterial (p=0.027) blood pressures and the maximum amplitude position of 24-h BP rhythm (p=0.036) on the other side was found.

Links

GA306/93/2192, research and development project
Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.
Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension
MSM 141100002, plan (intention)
Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
VS96097, research and development project
Name: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases