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@inproceedings{201167,
author = {Nováková, Marie and Hasin, Yonathan},
address = {Brno},
booktitle = {Biosignal 94},
edition = {1.},
keywords = {rat isolated cardiomyocytes;inotropic interventions},
language = {eng},
location = {Brno},
isbn = {80-02-00999-1},
pages = {187-189},
publisher = {Institut of Biomedical Engineering, Faculty of Electrical Engineering and Computation},
title = {Measurement of twitch contraction in isolated cardiac myocytes under the effect of various inotropic interventions},
year = {1994}
}
TY - JOUR
ID - 201167
AU - Nováková, Marie - Hasin, Yonathan
PY - 1994
TI - Measurement of twitch contraction in isolated cardiac myocytes under the effect of various inotropic interventions
PB - Institut of Biomedical Engineering, Faculty of Electrical Engineering and Computation
CY - Brno
SN - 8002009991
KW - rat isolated cardiomyocytes;inotropic interventions
N2 - The amplitude of contraction and the restitution of contractility were compared under control conditions (1.2 mM extracellular Ca2+ concentration, 0.2 Hz stimulation rate), after partial Ca2+ channel blockade by Verapamil (in concentration 10-6M), at decreased Ca2+concentration in the medium (0.6 mM) and in the presence of beta-receptor inhibitor Metoprolol (in concentration 10-4 M). In all three situations the amplitude of contraction decreased to 60% of control and the mechanical restitution was proportionaly reduced in all its course. It seems that Metoprolol - even in absence of catecholamines - decreases intracellular Ca2+ concentration.
ER -
NOVÁKOVÁ, Marie a Yonathan HASIN. Measurement of twitch contraction in isolated cardiac myocytes under the effect of various inotropic interventions. Online. In \textit{Biosignal 94}. 1. vyd. Brno: Institut of Biomedical Engineering, Faculty of Electrical Engineering and Computation, 1994. s.~187-189. ISBN~80-02-00999-1. [citováno 2024-04-23]
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