Effect of one year antihypertensive therapy with angiotensin I
converting enzyme (ACE) inhibitor on hemodynamic, hematological
and biochemical parameters. Effects of I/D ACE and M235T and
T174M angiotensinogen gene polymorphisms

J 1999

Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms

VAŠKŮ, Anna, Miroslav SOUČEK, Vladimír ZNOJIL, Lada RAMBOUSKOVÁ, Ivan ŘIHÁČEK et. al.

Basic information

Original name

Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms

Authors

VAŠKŮ, Anna (203 Czech Republic, guarantor), Miroslav SOUČEK (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic), Lada RAMBOUSKOVÁ (203 Czech Republic), Ivan ŘIHÁČEK (203 Czech Republic), Karel CÍDL (203 Czech Republic), Lenka STŘELCOVÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)

Edition

Scripta medica, Brno, Lékařská fakulta Masarykovy univerzity, 1999, 1211-3395

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/99:00001112

Organization unit

Faculty of Medicine

Keywords in English

quinapril; angiotensin-converting enzyme; angiotensinogen; ambulatory blood pressure monitoring

Abstract

V originále

The purpose of the study has been to evaluate the influence of one year angiotensin I-converting enzyme inhibitor (IACE) treatment on 24-h blood pressure (BP) and heart rate (HR) parameters, other hemodynamic (ECG, ECHO) parameters and hematological and biochemical tests in the genetic context of renin - angiotensin system gene polymorphisms. Eleven newly diagnosed essential hypertensives were treated with ACE inhibitor quinapril (Accupro, Gödecke, Berlin) for one year. All patients were genotyped for three polymorphisms - I/D of angiotensin I-converting enzyme and M235->T and T174->M of angiotensinogen genes, respectively. A decrease in the mean levels of systolic (p=0.001), mean arterial (p=0.002) and diastolic (p=0.003) blood pressures were found. No significant differences in ECG parameters nor differences in ECHO parameters became evident.However, a decrease in the red blood cell count (p=0.004) and an increase in the MCV of the RBCs (p=0.002) were observed. Differences in the blood glucose levels appeared to be associated with I/D ACE genotype (p=0.01).

Links

GA306/93/2192, research and development project

Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.

Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

VS96097, research and development project

Name: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases

Citovat

VAŠKŮ, Anna, Miroslav SOUČEK, Vladimír ZNOJIL, Lada RAMBOUSKOVÁ, Ivan ŘIHÁČEK, Karel CÍDL, Lenka STŘELCOVÁ and Jiří VÁCHA. Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms. Scripta medica. Brno: Lékařská fakulta Masarykovy univerzity, 1999, vol. 72, 2-3, p. 87-96. ISSN 1211-3395.

@article{207691,
   author = {Vašků, Anna and Souček, Miroslav and Znojil, Vladimír and Rambousková, Lada and Řiháček, Ivan and Cídl, Karel and Střelcová, Lenka and Vácha, Jiří},
   article_location = {Brno},
   article_number = {2-3},
   keywords = {quinapril; angiotensin-converting enzyme; angiotensinogen; ambulatory blood pressure monitoring},
   language = {eng},
   issn = {1211-3395},
   journal = {Scripta medica},
   title = {Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms},
   volume = {72},
   year = {1999}
}

TY  - JOUR
ID  - 207691
AU  - Vašků, Anna - Souček, Miroslav - Znojil, Vladimír - Rambousková, Lada - Řiháček, Ivan - Cídl, Karel - Střelcová, Lenka - Vácha, Jiří
PY  - 1999
TI  - Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms
JF  - Scripta medica
VL  - 72
IS  - 2-3
SP  - 87
EP  - 87
PB  - Lékařská fakulta Masarykovy univerzity
SN  - 12113395
KW  - quinapril
KW  - angiotensin-converting enzyme
KW  - angiotensinogen
KW  - ambulatory blood pressure monitoring
N2  - The purpose of the study has been to evaluate the influence of one year angiotensin I-converting enzyme inhibitor (IACE) treatment on 24-h blood pressure (BP) and heart rate (HR) parameters, other hemodynamic (ECG, ECHO) parameters and hematological and biochemical tests in the genetic context of renin - angiotensin system gene polymorphisms. Eleven newly diagnosed essential hypertensives were treated with ACE inhibitor quinapril (Accupro, Gödecke, Berlin) for one year. All patients were genotyped for three polymorphisms - I/D of angiotensin I-converting enzyme and M235->T and T174->M of angiotensinogen genes, respectively. A decrease in the mean levels of systolic (p=0.001), mean arterial (p=0.002) and diastolic (p=0.003) blood pressures were found. No significant differences in ECG parameters nor differences in ECHO parameters became evident.However, a decrease in the red blood cell count (p=0.004) and an increase in the MCV of the RBCs (p=0.002) were observed. Differences in the blood glucose levels appeared to be associated with I/D ACE genotype (p=0.01).
ER  -

VAŠKŮ, Anna, Miroslav SOUČEK, Vladimír ZNOJIL, Lada RAMBOUSKOVÁ, Ivan ŘIHÁČEK, Karel CÍDL, Lenka STŘELCOVÁ and Jiří VÁCHA. Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms. \textit{Scripta medica}. Brno: Lékařská fakulta Masarykovy univerzity, 1999, vol.~72, 2-3, p.~87-96. ISSN~1211-3395.

Detailed Information on Publication Record