a 2022

Candida dubliniensis and Candida albicans associated with early childhood caries in preschool children - a case-control study

CVANOVÁ, Michaela, Filip RŮŽIČKA, Martina KUKLETOVÁ, Břetislav LIPOVÝ, Daniela GACHOVÁ et. al.

Basic information

Original name

Candida dubliniensis and Candida albicans associated with early childhood caries in preschool children - a case-control study

Authors

CVANOVÁ, Michaela (203 Czech Republic), Filip RŮŽIČKA (203 Czech Republic), Martina KUKLETOVÁ (203 Czech Republic), Břetislav LIPOVÝ (203 Czech Republic), Daniela GACHOVÁ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Zdeněk DANĚK (203 Czech Republic), Veronika HOLÁ (203 Czech Republic), Michaela BARTOŠOVÁ (703 Slovakia), Jiří JARKOVSKÝ (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic) and Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

ESPID 2022, 2022

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/22:00126401

Organization unit

Faculty of Science

Keywords in English

candida; infectious; children; caries
Změněno: 30/3/2023 10:55, Mgr. Terezie Slámová

Abstract

V originále

Backgrounds: Dental caries is the worldwide most common infectious disease within the oral cavity. Caries in the primary dentition is referred to as Early Childhood Caries (ECC) and is associated with the presence of oral cariogenic bacteria. The role of other oral candidas in the ECC development is not fully understood. Our study aimed to investigate the occurrence of Candida sp. in preschool children according to their oral status. Methods: In this case-control association study, samples of dental plaque were collected from 164 children with ECC (with 6 or more of decayed,missed or filled teeth) and 147 children without dental caries. MALDI-TOF mass spectroscopy was used to identify Candida sp. Results: In all, 12 Candida sp. were identified in our study group. The occurrence of Candida sp. was significantly associated with sECC (odds ratio, OR 11.40, p < 0.001). The strongest association was with C. dubliniensis (OR 13.50, p < 0.001) and C. albicans (OR 6.83, p < 0.001). Conclusions/Learning Points: The presence of C. dubliniensis and C. albicans in dental plaque is an important indicator of dental caries development in preschool children. This research was supported by Ministry of Health of the Czech Republic, grant number: IGA NR8394-3/2005, NV17-30439A, NU20-08-00205, and by a project provided by University Hospital Brno, Ministry of Health Czech Republic – RVO (FNBr, 65269705). This publication has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 857560. Authors also thank the Research Infrastructure RECETOX RI (No LM2018121) and project CETOCOEN EXCELLENCE (No CZ.02.1.01/0.0/0.0/17_043/0009632) financed by the Ministry of Education, Youth and Sports for supportive background.

Links

EF17_043/0009632, research and development project
Name: CETOCOEN Excellence
LM2018121, research and development project
Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI
NR8394, research and development project
Name: Stav orálního zdraví u dětí sledovaných v programu ELSPAC Brno
Investor: Ministry of Health of the CR
NU20-08-00205, research and development project
Name: Molekulární etiopatogeneze apikální periodontitidy a odontogenních cyst
Investor: Ministry of Health of the CR, Subprogram 1 - standard
NV17-30439A, research and development project
Name: Moderní biotechnologické a behaviorální přístupy ve výzkumu zubního kazu a strategie jeho prevence