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@article{2210924,
author = {Štros, Michal and Volfová Polanská, Eva and Hlaváčová, Tereza and Skládal, Petr},
article_location = {Basel},
article_number = {4},
doi = {http://dx.doi.org/10.3390/biom12040544},
keywords = {HMGB1; plasma/serum; ELISA; EMSA; immunosensor; COVID-19},
language = {eng},
issn = {2218-273X},
journal = {Biomolecules},
title = {Progress in Assays of HMGB1 Levels in Human Plasma-The Potential Prognostic Value in COVID-19},
url = {https://www.mdpi.com/2218-273X/12/4/544},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 2210924
AU - Štros, Michal - Volfová Polanská, Eva - Hlaváčová, Tereza - Skládal, Petr
PY - 2022
TI - Progress in Assays of HMGB1 Levels in Human Plasma-The Potential Prognostic Value in COVID-19
JF - Biomolecules
VL - 12
IS - 4
SP - 1-11
EP - 1-11
PB - MDPI
SN - 2218273X
KW - HMGB1
KW - plasma/serum
KW - ELISA
KW - EMSA
KW - immunosensor
KW - COVID-19
UR - https://www.mdpi.com/2218-273X/12/4/544
N2 - Extracellular HMGB1 protein is known to induce inflammatory responses leading to an inflammatory storm. The outbreak of the Severe Acute Respiratory Syndrome COVID-19 due to the SARS-CoV-2 virus has resulted in a huge health concern worldwide. Recent data revealed that plasma/serum HMGB1 levels of patients suffering from inflammation-mediated disorders-such as COVID-19, cancer, and autoimmune disorders-correlate positively with disease severity and vice versa. A late release of HMGB1 in sepsis suggests the existence of a wide therapeutic window for treating sepsis. Rapid and accurate methods for the detection of HMGB1 levels in plasma/serum are, therefore, of great importance for monitoring the occurrence, treatment success, and survival prediction of patients with inflammation-mediated diseases. In this review, we briefly explain the role of HMGB1 in the cell, and particularly the involvement of extracellular HMGB1 (released from the cells) in inflammation-mediated diseases, with an emphasis on COVID-19. The current assays to measure HMGB1 levels in human plasma-Western blotting, ELISA, EMSA, and a new approach based on electrochemical immunosensors, including some of our preliminary results-are presented and thoroughly discussed.
ER -
ŠTROS, Michal, Eva VOLFOVÁ POLANSKÁ, Tereza HLAVÁČOVÁ and Petr SKLÁDAL. Progress in Assays of HMGB1 Levels in Human Plasma-The Potential Prognostic Value in COVID-19. \textit{Biomolecules}. Basel: MDPI, 2022, vol.~12, No~4, p.~1-11. ISSN~2218-273X. Available from: https://dx.doi.org/10.3390/biom12040544.
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