| ONDROUŠKOVÁ, Eva, Michaela BOHÚNOVÁ, Kristýna ZÁVACKÁ, Patrik ČECH, Petra ŠMUHAŘOVÁ, Miroslav BOUDNÝ, Martina ORŠULOVÁ, Anna PANOVSKÁ, Lenka RADOVÁ, Michael DOUBEK, Karla PLEVOVÁ and Marie JAROŠOVÁ. Duplication of 8q24 in Chronic Lymphocytic Leukemia: Cytogenetic and Molecular Biologic Analysis of MYC Aberrations. Frontiers in Oncology. Lausanne: Frontiers Media S.A., vol. 12, June 2022, p. 1-11. ISSN 2234-943X. doi:10.3389/fonc.2022.859618. 2022. |
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@article{2211030,
author = {Ondroušková, Eva and Bohúnová, Michaela and Závacká, Kristýna and Čech, Patrik and Šmuhařová, Petra and Boudný, Miroslav and Oršulová, Martina and Panovská, Anna and Radová, Lenka and Doubek, Michael and Plevová, Karla and Jarošová, Marie},
article_location = {Lausanne},
article_number = {June 2022},
doi = {http://dx.doi.org/10.3389/fonc.2022.859618},
keywords = {chronic lymphocytic leukemia; MYC; complex karyotype; 8q24 gain; prognosis},
language = {eng},
issn = {2234-943X},
journal = {Frontiers in Oncology},
title = {Duplication of 8q24 in Chronic Lymphocytic Leukemia: Cytogenetic and Molecular Biologic Analysis of MYC Aberrations},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2022.859618/full},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 2211030
AU - Ondroušková, Eva - Bohúnová, Michaela - Závacká, Kristýna - Čech, Patrik - Šmuhařová, Petra - Boudný, Miroslav - Oršulová, Martina - Panovská, Anna - Radová, Lenka - Doubek, Michael - Plevová, Karla - Jarošová, Marie
PY - 2022
TI - Duplication of 8q24 in Chronic Lymphocytic Leukemia: Cytogenetic and Molecular Biologic Analysis of MYC Aberrations
JF - Frontiers in Oncology
VL - 12
IS - June 2022
SP - 1-11
EP - 1-11
PB - Frontiers Media S.A.
SN - 2234943X
KW - chronic lymphocytic leukemia
KW - MYC
KW - complex karyotype
KW - 8q24 gain
KW - prognosis
UR - https://www.frontiersin.org/articles/10.3389/fonc.2022.859618/full
N2 - Chronic lymphocytic leukemia (CLL) with cytogenetics findings, such as complex karyotype and deletions of TP53 or ATM, is associated with adverse clinical outcomes. Additional chromosomal abnormalities further stratify patients into groups with diverse prognoses. Gain of 8q24 is one of the abnormalities considered as prognostically unfavorable. In our study, we performed a FISH analysis in an initial cohort of 303 consecutive CLL patients and determined the frequency of +8q to be 6.3 %. Our analysis confirmed the association with TP53/ATM aberrations and CK, as the frequency of +8q reached 26.7 % in an extended delTP53/ATM+CK cohort. M-FISH analysis enabled the identification of partner chromosomes where the segment of the duplicated 8q arm was localized. More detailed mapping of the gained 8q region using the M-BAND method determined the smallest amplified region 8q23-8qter. We observed significantly shorter overall survival (OS; 9.0 years in +8q-positive vs. 10.6 years in +8q-negative; p=0.02) and detected slightly higher MYC mRNA/protein levels in +8q-positive vs. +8q-negative patients.
ER -
ONDROUŠKOVÁ, Eva, Michaela BOHÚNOVÁ, Kristýna ZÁVACKÁ, Patrik ČECH, Petra ŠMUHAŘOVÁ, Miroslav BOUDNÝ, Martina ORŠULOVÁ, Anna PANOVSKÁ, Lenka RADOVÁ, Michael DOUBEK, Karla PLEVOVÁ and Marie JAROŠOVÁ. Duplication of 8q24 in Chronic Lymphocytic Leukemia: Cytogenetic and Molecular Biologic Analysis of MYC Aberrations. \textit{Frontiers in Oncology}. Lausanne: Frontiers Media S.A., vol.~12, June 2022, p.~1-11. ISSN~2234-943X. doi:10.3389/fonc.2022.859618. 2022.
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