J 2022

Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient

ARPÁŠ, Tomáš, Hana JELÍNKOVÁ, Štěpán HRABOVSKÝ, Martina ORŠULOVÁ, Zuzana VRZALOVÁ et. al.

Basic information

Original name

Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient

Authors

ARPÁŠ, Tomáš (703 Slovakia, belonging to the institution), Hana JELÍNKOVÁ (203 Czech Republic), Štěpán HRABOVSKÝ (203 Czech Republic, belonging to the institution), Martina ORŠULOVÁ (703 Slovakia, belonging to the institution), Zuzana VRZALOVÁ (203 Czech Republic, belonging to the institution), Veronika NAVRKALOVÁ (203 Czech Republic, belonging to the institution), Eva BRHELOVÁ (203 Czech Republic, belonging to the institution), Lenka BRYJOVÁ (203 Czech Republic, belonging to the institution), Alena BULIKOVÁ (203 Czech Republic, belonging to the institution), Eva ONDROUŠKOVÁ (203 Czech Republic, belonging to the institution), Markéta ŠEJNOHOVÁ (203 Czech Republic, belonging to the institution), František FOLBER (203 Czech Republic, belonging to the institution), Petra ŠEDOVÁ (203 Czech Republic, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Marie JAROŠOVÁ (203 Czech Republic, belonging to the institution) and Michael DOUBEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

CLINICAL CASE REPORTS, ENGLAND, WILEY, 2022, 2050-0904

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 0.700

RIV identification code

RIV/00216224:14110/22:00126446

Organization unit

Faculty of Medicine

DOI

UT WoS

000818987200123

Keywords in English

acute lymphoblastic leukemia; blinatumomab; CAR-T therapy; inotuzumab ozogamicin; near-haploid

Tags

Tags

International impact, Reviewed
Změněno: 17/10/2024 13:42, Ing. Monika Szurmanová, Ph.D.

Abstract

V originále

Near-haploid acute lymphoblastic leukemia is rare subgroup of the disease, which is very important due to very poor prognosis and resistance to treatment including novel monoclonal antibodies and CAR-T therapy.

Links

EF16_026/0008448, research and development project
Name: Analýza českých genomů pro teranostiku
LM2018133, research and development project
Name: Český národní uzel Evropské infrastruktury pro translační medicínu (Acronym: EATRIS-ERIC-CZ)
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/1595/2020, interní kód MU
Name: Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit VIII (Acronym: VýDiTeHeMa VIII)
Investor: Masaryk University
MUNI/11/SUP/22/2020, interní kód MU
Name: Zavedení technologie CRISPR/Cas9 pro funkční studie u familiárních hematopoetických onemocnění
Investor: Masaryk University
NU20-08-00137, research and development project
Name: Vyhledávání a funkční testování variant genů predisponujících k familiárním onemocněním krvetvorby
Investor: Ministry of Health of the CR, Searching and functional testing of gene variants predisposing to familial haematopoietic disorders, Subprogram 1 - standard
TN01000013, research and development project
Name: Personalizovaná medicína - diagnostika a terapie
Investor: Technology Agency of the Czech Republic, Personalized Medicine – Diagnostics and Therapy
90133, large research infrastructures
Name: EATRIS-CZ III