J 2022

The reduction of hippocampal volume in Parkinson's disease

ŘÍHA, Pavel, Luboš BRABENEC, Radek MAREČEK, Ivan REKTOR, Irena REKTOROVÁ et. al.

Basic information

Original name

The reduction of hippocampal volume in Parkinson's disease

Authors

ŘÍHA, Pavel (203 Czech Republic, belonging to the institution), Luboš BRABENEC (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution)

Edition

Journal of Neural Transmission, WIEN, SPRINGER WIEN, 2022, 0300-9564

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.300

RIV identification code

RIV/00216224:14740/22:00126466

Organization unit

Central European Institute of Technology

DOI

UT WoS

000751224300001

Keywords in English

Parkinson's disease; Aging; Hippocampus-to-cortex volume ratio; Processing speed

Tags

Tags

International impact, Reviewed
Změněno: 10/10/2024 09:57, Ing. Jana Kuchtová

Abstract

V originále

The volume of the hippocampus decreases more slowly than the volume of the cortex during normal aging. We explored changes in the hippocampus-to-cortex volume (HV:CTV) ratio with increasing age in non-demented Parkinson's disease (PD) patients as compared to healthy controls (HC). We also evaluated the association between the HV:CTV ratio and cognitive outcomes. Altogether 130 participants without dementia aged 51-88 years were consecutively enrolled, including 54 PD patients (mean age 67, standard deviation (SD) 8 years) and 76 HC (mean age 69, SD 7 years). All participants underwent structural magnetic resonance examination and psychological evaluation. Hippocampal and cortex volumes were determined from T1 and FLAIR scans using FreeSurfer software, and the HV:CTV ratio was calculated. Regression lines for age-dependence of the HV:CTV ratio for PD and HC groups were calculated. We further assessed the association between the HV:CTV ratio and cognitive tests examining hippocampus-related cognitive functions. PD patients and age-matched HC showed a significant difference in age-dependence of HV:CTV ratio (p value = 0.012), with a decreasing slope in PD and increasing slope in HC. In the PD group, a significant correlation (R = 0.561, p = 0.024) was observed between the HV:CTV ratio and the Digit Symbol-Coding test. The reduction of HV:CTV ratio is accelerated in pathological aging due to PD pathology. The HV:CTV ratio was associated with impaired processing speed, i.e., the cognitive function that is linked to subcortical alterations of both associated basal ganglia circuitry and the hippocampus.

Links

GA21-25953S, research and development project
Name: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Acronym: DBS3D)
Investor: Czech Science Foundation, Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective
NU20-04-00294, research and development project
Name: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat
Investor: Ministry of Health of the CR, Diagnostics of Lewy body diseases in prodromal stage based on multimodal data analysis
734718, interní kód MU
Name: Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology (Acronym: CoBeN)
Investor: European Union, MSCA Marie Skłodowska-Curie Actions (Excellent Science)
90129, large research infrastructures
Name: Czech-BioImaging II