Detailed Information on Publication Record
2022
The reduction of hippocampal volume in Parkinson's disease
ŘÍHA, Pavel, Luboš BRABENEC, Radek MAREČEK, Ivan REKTOR, Irena REKTOROVÁ et. al.Basic information
Original name
The reduction of hippocampal volume in Parkinson's disease
Authors
ŘÍHA, Pavel (203 Czech Republic, belonging to the institution), Luboš BRABENEC (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution)
Edition
Journal of Neural Transmission, WIEN, SPRINGER WIEN, 2022, 0300-9564
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
Austria
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.300
RIV identification code
RIV/00216224:14740/22:00126466
Organization unit
Central European Institute of Technology
UT WoS
000751224300001
Keywords in English
Parkinson's disease; Aging; Hippocampus-to-cortex volume ratio; Processing speed
Tags
International impact, Reviewed
Změněno: 10/10/2024 09:57, Ing. Jana Kuchtová
Abstract
V originále
The volume of the hippocampus decreases more slowly than the volume of the cortex during normal aging. We explored changes in the hippocampus-to-cortex volume (HV:CTV) ratio with increasing age in non-demented Parkinson's disease (PD) patients as compared to healthy controls (HC). We also evaluated the association between the HV:CTV ratio and cognitive outcomes. Altogether 130 participants without dementia aged 51-88 years were consecutively enrolled, including 54 PD patients (mean age 67, standard deviation (SD) 8 years) and 76 HC (mean age 69, SD 7 years). All participants underwent structural magnetic resonance examination and psychological evaluation. Hippocampal and cortex volumes were determined from T1 and FLAIR scans using FreeSurfer software, and the HV:CTV ratio was calculated. Regression lines for age-dependence of the HV:CTV ratio for PD and HC groups were calculated. We further assessed the association between the HV:CTV ratio and cognitive tests examining hippocampus-related cognitive functions. PD patients and age-matched HC showed a significant difference in age-dependence of HV:CTV ratio (p value = 0.012), with a decreasing slope in PD and increasing slope in HC. In the PD group, a significant correlation (R = 0.561, p = 0.024) was observed between the HV:CTV ratio and the Digit Symbol-Coding test. The reduction of HV:CTV ratio is accelerated in pathological aging due to PD pathology. The HV:CTV ratio was associated with impaired processing speed, i.e., the cognitive function that is linked to subcortical alterations of both associated basal ganglia circuitry and the hippocampus.
Links
GA21-25953S, research and development project |
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NU20-04-00294, research and development project |
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734718, interní kód MU |
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90129, large research infrastructures |
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