2022
The reduction of hippocampal volume in Parkinson's disease
ŘÍHA, Pavel; Luboš BRABENEC; Radek MAREČEK; Ivan REKTOR; Irena REKTOROVÁ et. al.Basic information
Original name
The reduction of hippocampal volume in Parkinson's disease
Authors
ŘÍHA, Pavel (203 Czech Republic, belonging to the institution); Luboš BRABENEC (203 Czech Republic, belonging to the institution); Radek MAREČEK (203 Czech Republic, belonging to the institution); Ivan REKTOR (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution)
Edition
Journal of Neural Transmission, WIEN, SPRINGER WIEN, 2022, 0300-9564
Other information
Language
English
Type of outcome
Article in a journal
Field of Study
30103 Neurosciences
Country of publisher
Austria
Confidentiality degree
is not subject to a state or trade secret
References:
Impact factor
Impact factor: 3.300
RIV identification code
RIV/00216224:14740/22:00126466
Organization unit
Central European Institute of Technology
UT WoS
000751224300001
EID Scopus
2-s2.0-85124293730
Keywords in English
Parkinson's disease; Aging; Hippocampus-to-cortex volume ratio; Processing speed
Tags
International impact, Reviewed
Changed: 10/10/2024 09:57, Ing. Jana Kuchtová
Abstract
V originále
The volume of the hippocampus decreases more slowly than the volume of the cortex during normal aging. We explored changes in the hippocampus-to-cortex volume (HV:CTV) ratio with increasing age in non-demented Parkinson's disease (PD) patients as compared to healthy controls (HC). We also evaluated the association between the HV:CTV ratio and cognitive outcomes. Altogether 130 participants without dementia aged 51-88 years were consecutively enrolled, including 54 PD patients (mean age 67, standard deviation (SD) 8 years) and 76 HC (mean age 69, SD 7 years). All participants underwent structural magnetic resonance examination and psychological evaluation. Hippocampal and cortex volumes were determined from T1 and FLAIR scans using FreeSurfer software, and the HV:CTV ratio was calculated. Regression lines for age-dependence of the HV:CTV ratio for PD and HC groups were calculated. We further assessed the association between the HV:CTV ratio and cognitive tests examining hippocampus-related cognitive functions. PD patients and age-matched HC showed a significant difference in age-dependence of HV:CTV ratio (p value = 0.012), with a decreasing slope in PD and increasing slope in HC. In the PD group, a significant correlation (R = 0.561, p = 0.024) was observed between the HV:CTV ratio and the Digit Symbol-Coding test. The reduction of HV:CTV ratio is accelerated in pathological aging due to PD pathology. The HV:CTV ratio was associated with impaired processing speed, i.e., the cognitive function that is linked to subcortical alterations of both associated basal ganglia circuitry and the hippocampus.
Links
| GA21-25953S, research and development project |
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| NU20-04-00294, research and development project |
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| 734718, interní kód MU |
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| 90129, large research infrastructures |
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