Antioxidant and Anti-Inflammatory Activity of Five Medicinal
Mushrooms of the Genus Pleurotus

J 2022

Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus

STASTNY, J.., P. MARSIK, J. TAUCHEN, M. BOZIK, A. MASCELLANI et. al.

Basic information

Original name

Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus

Authors

STASTNY, J.., P. MARSIK, J. TAUCHEN, M. BOZIK, A. MASCELLANI, J. HAVLIK, P. LANDA, I. JABLONSKY, Jakub TREML (203 Czech Republic, belonging to the institution), Petra HERCZOGOVÁ (703 Slovakia, belonging to the institution), R. BLEHA, A. SYNYTSYA and P. KLOUCEK (guarantor)

Edition

Antioxidants, Basel, MDPI, 2022, 2076-3921

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.000

RIV identification code

RIV/00216224:14160/22:00129822

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/antiox11081569

UT WoS

000846407200001

Keywords in English

bioactivity; secondary metabolites; oyster mushroom; basidiomycetes; pink oyster mushroom; cyclooxygenase-2; immunomodulatory effect; radical scavenging effect; inflammation; Indian oyster mushroom

Abstract

V originále

Within the group of higher fungi, edible medicinal mushrooms have a long history of being used as food and in folk medicine. These species contain biologically active substances with many potential beneficial effects on human health. The Pleurotus genus is representative of medicinal mushrooms because Pleurotus ostreatus is one of the most commonly cultivated culinary mushrooms. In our study, we focused on lesser-known species in the genus Pleurotus and measured their antioxidant and anti-inflammatory activity. We prepared extracts of the mushrooms and analyzed them using HPLC−HRMS, GC−MS, and 1H-NMR. Significant differences in biological activities were found among the Pleurotus spp. extracts. A MeOH extract of P. flabellatus was the most active as a radical scavenger with the highest ORAC, while a chloroform extract had significant anti-inflammatory COX-2 activity. The 80% MeOH extract of P. flabellatus contained the highest amounts of ergosterol, ergothioneine, and mannitol. The 80% MeOH extract of P. ostreatus Florida was the most active in the NF-κB inhibition assay and had the highest content of β-glucans (43.3% by dry weight). Given the antioxidant and anti-inflammatory properties of P. flabellatus, the potential therapeutic usefulness of this species is worth evaluating through in-depth investigations and confirmation by clinical trials.

Links

MUNI/A/1654/2020, interní kód MU

Name: Testování biologické aktivity vybraných přírodních látek in vitro

Investor: Masaryk University

Citovat

STASTNY, J.., P. MARSIK, J. TAUCHEN, M. BOZIK, A. MASCELLANI, J. HAVLIK, P. LANDA, I. JABLONSKY, Jakub TREML, Petra HERCZOGOVÁ, R. BLEHA, A. SYNYTSYA and P. KLOUCEK. Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus. Antioxidants. Basel: MDPI, 2022, vol. 11, No 8, p. 1-16. ISSN 2076-3921. Available from: https://dx.doi.org/10.3390/antiox11081569.

@article{2212614,
   author = {Stastny, J.. and Marsik, P. and Tauchen, J. and Bozik, M. and Mascellani, A. and Havlik, J. and Landa, P. and Jablonsky, I. and Treml, Jakub and Herczogová, Petra and Bleha, R. and Synytsya, A. and Kloucek, P.},
   article_location = {Basel},
   article_number = {8},
   doi = {http://dx.doi.org/10.3390/antiox11081569},
   keywords = {bioactivity; secondary metabolites; oyster mushroom; basidiomycetes; pink oyster mushroom; cyclooxygenase-2; immunomodulatory effect; radical scavenging effect; inflammation; Indian oyster mushroom},
   language = {eng},
   issn = {2076-3921},
   journal = {Antioxidants},
   title = {Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus},
   url = {https://www.mdpi.com/2076-3921/11/8/1569/htm},
   volume = {11},
   year = {2022}
}

TY  - JOUR
ID  - 2212614
AU  - Stastny, J.. - Marsik, P. - Tauchen, J. - Bozik, M. - Mascellani, A. - Havlik, J. - Landa, P. - Jablonsky, I. - Treml, Jakub - Herczogová, Petra - Bleha, R. - Synytsya, A. - Kloucek, P.
PY  - 2022
TI  - Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus
JF  - Antioxidants
VL  - 11
IS  - 8
SP  - 1-16
EP  - 1-16
PB  - MDPI
SN  - 20763921
KW  - bioactivity
KW  - secondary metabolites
KW  - oyster mushroom
KW  - basidiomycetes
KW  - pink oyster mushroom
KW  - cyclooxygenase-2
KW  - immunomodulatory effect
KW  - radical scavenging effect
KW  - inflammation
KW  - Indian oyster mushroom
UR  - https://www.mdpi.com/2076-3921/11/8/1569/htm
N2  - Within the group of higher fungi, edible medicinal mushrooms have a long history of being used as food and in folk medicine. These species contain biologically active substances with many potential beneficial effects on human health. The Pleurotus genus is representative of medicinal mushrooms because Pleurotus ostreatus is one of the most commonly cultivated culinary mushrooms. In our study, we focused on lesser-known species in the genus Pleurotus and measured their antioxidant and anti-inflammatory activity. We prepared extracts of the mushrooms and analyzed them using HPLC−HRMS, GC−MS, and 1H-NMR. Significant differences in biological activities were found among the Pleurotus spp. extracts. A MeOH extract of P. flabellatus was the most active as a radical scavenger with the highest ORAC, while a chloroform extract had significant anti-inflammatory COX-2 activity. The 80% MeOH extract of P. flabellatus contained the highest amounts of ergosterol, ergothioneine, and mannitol. The 80% MeOH extract of P. ostreatus Florida was the most active in the NF-κB inhibition assay and had the highest content of β-glucans (43.3% by dry weight). Given the antioxidant and anti-inflammatory properties of P. flabellatus, the potential therapeutic usefulness of this species is worth evaluating through in-depth investigations and confirmation by clinical trials.
ER  -

STASTNY, J.., P. MARSIK, J. TAUCHEN, M. BOZIK, A. MASCELLANI, J. HAVLIK, P. LANDA, I. JABLONSKY, Jakub TREML, Petra HERCZOGOVÁ, R. BLEHA, A. SYNYTSYA and P. KLOUCEK. Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus. \textit{Antioxidants}. Basel: MDPI, 2022, vol.~11, No~8, p.~1-16. ISSN~2076-3921. Available from: https://dx.doi.org/10.3390/antiox11081569.

Detailed Information on Publication Record