Hodnotenie vlastností vybraných karbamátov

HEGEDUŠ, Marina, Lucia VRÁBLOVÁ, Dominika PINDJAKOVÁ, Tomáš STRHÁRSKY, Tomáš GONĚC and Josef JAMPÍLEK. Hodnotenie vlastností vybraných karbamátov (Investigation of Properties of Selected Carbamates). In Viglašová Eva, Chovancová Mária, Sebechlebská Táňa, Gajanová Dagmara. Študentská vedecká konferencia PriF UK 2022 Zborník recenzovaných príspevkov. Bratislava: Univerzita Komenského v Bratislave, 2022, p. 766-771, 1189 pp. ISBN 978-80-223-5385-4.

Basic information

Original name

Hodnotenie vlastností vybraných karbamátov

Name (in English)

Investigation of Properties of Selected Carbamates

Authors

HEGEDUŠ, Marina (703 Slovakia), Lucia VRÁBLOVÁ (703 Slovakia), Dominika PINDJAKOVÁ (703 Slovakia), Tomáš STRHÁRSKY (703 Slovakia, belonging to the institution), Tomáš GONĚC (203 Czech Republic, guarantor, belonging to the institution) and Josef JAMPÍLEK (203 Czech Republic)

Edition

Bratislava, Študentská vedecká konferencia PriF UK 2022 Zborník recenzovaných príspevkov, p. 766-771, 1189 pp. 2022

Publisher

Univerzita Komenského v Bratislave

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Other information

Language

Slovak

Type of outcome

Stať ve sborníku

Field of Study

10406 Analytical chemistry

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

storage medium (CD, DVD, flash disk)

References:

URL

RIV identification code

RIV/00216224:14160/22:00126517

Organization unit

Faculty of Pharmacy

ISBN

978-80-223-5385-4

Keywords in English

lipohilicity; HPLC; capacity factor; retention; stability

Tags

rivok, ÚChL

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Abstract

V originále

This work deals with the evaluation of lipophilicity and stability of selected carbamates using high performance liquid chromatography. A method using C18 reverse stationary phase and isocratic conditions was used to determine lipophilicity. The methanol:water mobile phase was used to determine the capacity factor k, while the methanol:acetate buffer (pH 6.5 and pH 7.4) was used to determine the distribution coefficient D. Prediction of lipophilicity by in silico methods was performed using three software with different algorithms: ChemBioDraw Ultra, ACD/Percepta and MOLinspiration. The carbamate with the weakest steric protection, i.e. with the expected highest degradability, was chosen for stability monitoring. The developed HPLC method using phenyl stationary phase and acetonitrile:phosphate buffer (pH 2.5) as the mobile phase provided sufficient resolution between the studied carbamate and its degradant, pattern anilide.

In English

This work deals with the evaluation of lipophilicity and stability of selected carbamates using high performance liquid chromatography. A method using C18 reverse stationary phase and isocratic conditions was used to determine lipophilicity. The methanol:water mobile phase was used to determine the capacity factor k, while the methanol:acetate buffer (pH 6.5 and pH 7.4) was used to determine the distribution coefficient D. Prediction of lipophilicity by in silico methods was performed using three software with different algorithms: ChemBioDraw Ultra, ACD/Percepta and MOLinspiration. The carbamate with the weakest steric protection, i.e. with the expected highest degradability, was chosen for stability monitoring. The developed HPLC method using phenyl stationary phase and acetonitrile:phosphate buffer (pH 2.5) as the mobile phase provided sufficient resolution between the studied carbamate and its degradant, pattern anilide.