HEGEDUŠ, Marina, Lucia VRÁBLOVÁ, Dominika PINDJAKOVÁ, Tomáš STRHÁRSKY, Tomáš GONĚC and Josef JAMPÍLEK. Hodnotenie vlastností vybraných karbamátov (Investigation of Properties of Selected Carbamates). In Viglašová Eva, Chovancová Mária, Sebechlebská Táňa, Gajanová Dagmara. Študentská vedecká konferencia PriF UK 2022 Zborník recenzovaných príspevkov. Bratislava: Univerzita Komenského v Bratislave, 2022, p. 766-771, 1189 pp. ISBN 978-80-223-5385-4.
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Basic information
Original name Hodnotenie vlastností vybraných karbamátov
Name (in English) Investigation of Properties of Selected Carbamates
Authors HEGEDUŠ, Marina (703 Slovakia), Lucia VRÁBLOVÁ (703 Slovakia), Dominika PINDJAKOVÁ (703 Slovakia), Tomáš STRHÁRSKY (703 Slovakia, belonging to the institution), Tomáš GONĚC (203 Czech Republic, guarantor, belonging to the institution) and Josef JAMPÍLEK (203 Czech Republic).
Edition Bratislava, Študentská vedecká konferencia PriF UK 2022 Zborník recenzovaných príspevkov, p. 766-771, 1189 pp. 2022.
Publisher Univerzita Komenského v Bratislave
Other information
Original language Slovak
Type of outcome Proceedings paper
Field of Study 10406 Analytical chemistry
Country of publisher Slovakia
Confidentiality degree is not subject to a state or trade secret
Publication form storage medium (CD, DVD, flash disk)
WWW URL
RIV identification code RIV/00216224:14160/22:00126517
Organization unit Faculty of Pharmacy
ISBN 978-80-223-5385-4
Keywords in English lipohilicity; HPLC; capacity factor; retention; stability
Tags rivok, ÚChL
Changed by Changed by: PharmDr. Tomáš Goněc, Ph.D., učo 39112. Changed: 26/8/2022 14:20.
Abstract
This work deals with the evaluation of lipophilicity and stability of selected carbamates using high performance liquid chromatography. A method using C18 reverse stationary phase and isocratic conditions was used to determine lipophilicity. The methanol:water mobile phase was used to determine the capacity factor k, while the methanol:acetate buffer (pH 6.5 and pH 7.4) was used to determine the distribution coefficient D. Prediction of lipophilicity by in silico methods was performed using three software with different algorithms: ChemBioDraw Ultra, ACD/Percepta and MOLinspiration. The carbamate with the weakest steric protection, i.e. with the expected highest degradability, was chosen for stability monitoring. The developed HPLC method using phenyl stationary phase and acetonitrile:phosphate buffer (pH 2.5) as the mobile phase provided sufficient resolution between the studied carbamate and its degradant, pattern anilide.
Abstract (in English)
This work deals with the evaluation of lipophilicity and stability of selected carbamates using high performance liquid chromatography. A method using C18 reverse stationary phase and isocratic conditions was used to determine lipophilicity. The methanol:water mobile phase was used to determine the capacity factor k, while the methanol:acetate buffer (pH 6.5 and pH 7.4) was used to determine the distribution coefficient D. Prediction of lipophilicity by in silico methods was performed using three software with different algorithms: ChemBioDraw Ultra, ACD/Percepta and MOLinspiration. The carbamate with the weakest steric protection, i.e. with the expected highest degradability, was chosen for stability monitoring. The developed HPLC method using phenyl stationary phase and acetonitrile:phosphate buffer (pH 2.5) as the mobile phase provided sufficient resolution between the studied carbamate and its degradant, pattern anilide.
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