Morbidity and psychomotor development of offspring of women with gestational diabetes: a 5-year follow-up

BARTÁKOVÁ, Vendula, Beáta KREJČÍŘOVÁ, Katarína CHALÁSOVÁ, Petr JANKŮ and Kateřina KAŇKOVÁ. Morbidity and psychomotor development of offspring of women with gestational diabetes: a 5-year follow-up. BMC PEDIATRICS. London: BMC, 2022, vol. 22, No 1, p. 1-9. ISSN 1471-2431. Available from: https://dx.doi.org/10.1186/s12887-022-03543-4.

Basic information

• Original name: Morbidity and psychomotor development of offspring of women with gestational diabetes: a 5-year follow-up
• Authors: BARTÁKOVÁ, Vendula (203 Czech Republic, guarantor, belonging to the institution), Beáta KREJČÍŘOVÁ (703 Slovakia, belonging to the institution), Katarína CHALÁSOVÁ (703 Slovakia, belonging to the institution), Petr JANKŮ (203 Czech Republic) and Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution).
• Edition: BMC PEDIATRICS, London, BMC, 2022, 1471-2431.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30202 Endocrinology and metabolism
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.400
• RIV identification code: RIV/00216224:14110/22:00129681
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1186/s12887-022-03543-4
• UT WoS: 000842150100001
• Keywords in English: Gestational diabetes mellitus; Obesity; Offspring; Pregnancy; Prospective study
• Tags: 14110518
• Tags: International impact, Reviewed

Abstract

Background Gestational diabetes mellitus (GDM) represents a risk factor for both mother and her offspring in a short-term (perinatal morbidity) and long-term horizon (postpartum diabetes or foetal programming). Several studies focused at peri/postnatal outcomes of GDM mother´s offspring, however relatively few (and none in Czech population) were designed as prospective. The aim of the study was to ascertain eventual anthropometric and developmental abnormalities and/or morbidity in offspring of GDM mothers compare to controls in a 5-year follow-up using a parent-reported parameters related to psychomotor development and common paediatric morbidities including a sub-study of offspring of GDM mothers experiencing adverse perinatal outcomes. Methods A 5 year follow up study of offspring of GDM mothers (n = 26) vs those with a normal pregnancy (n = 63). An electronic questionnaire was used to obtain the parameters (such as growth, psychomotor development, vaccination, morbidity history etc.) available to parents from the parent-held infant health record. Data on pregnancy and delivery were available from the previous study. Results Offspring of GDM mothers had delayed psychomotor development in early childhood, but in 5 years of age they seemed to gradually achieve results of a control group. Children with macrosomia had a higher percentile of weight-for-height and were significantly more frequently ill than those with a normal birth weight. Offspring of obese mothers had worse verbal language skills in early childhood and a higher percentile of weight-for-height. Conclusion Maternal gestational diabetes and obesity can be considered an important determinant of postnatal offspring development and health status, which further advocates for broader implementation of preventive strategies.

Links

• NV18-01-00046, research and development project: Name: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministry of Health of the CR