a 2022

The effect of potential carcinogen harman on selected cytochrome P450 enzymes in rats

KLÁSKOVÁ, Eva, Markéta STRAKOŠOVÁ, Jan JUŘICA and Ondřej ZENDULKA

Basic information

Original name

The effect of potential carcinogen harman on selected cytochrome P450 enzymes in rats

Authors

KLÁSKOVÁ, Eva, Markéta STRAKOŠOVÁ, Jan JUŘICA and Ondřej ZENDULKA

Edition

27th Interdisciplinary Toxicology Conference, 2022

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Organization unit

Faculty of Medicine

ISSN

Keywords in English

cytochrome P450, harman, metabolic activity, drug-drug interactions
Změněno: 2/9/2022 08:23, PharmDr. Eva Klásková

Abstract

V originále

Harman is a heterocyclic aromatic amine discovered in coffee, cigarette smoke, roasted meat, or fish. However, carcinogenic properties of harmane were proved - partly explained by its interaction via the AhR receptor and induction of CYP1A1. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of 75 % of drugs used in clinical practice. Our study aimed to determine the effects of harman on the most important CYP variants in a preclinical experiment.

Links

MUNI/A/1440/2021, interní kód MU
Name: Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii (Acronym: Farm-Pre-Klin)
Investor: Masaryk University