| NOVOTNA, Lenka, Zdenek CHLUP, Josef JAROŠ, Klára ČÁSTKOVÁ, Daniel DRDLIK, Jakub POSPÍŠIL, Aleš HAMPL, Irena KOUTNÁ and Jaroslav CIHLAR. Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation. JOURNAL OF ASIAN CERAMIC SOCIETIES. ABINGDON: TAYLOR & FRANCIS LTD, 2022, vol. 10, No 2, p. 356-369. ISSN 2187-0764. Available from: https://dx.doi.org/10.1080/21870764.2022.2053278. |
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@article{2215482,
author = {Novotna, Lenka and Chlup, Zdenek and Jaroš, Josef and Částková, Klára and Drdlik, Daniel and Pospíšil, Jakub and Hampl, Aleš and Koutná, Irena and Cihlar, Jaroslav},
article_location = {ABINGDON},
article_number = {2},
doi = {http://dx.doi.org/10.1080/21870764.2022.2053278},
keywords = {Bioceramics; scaffold; calcium phosphate; silica; compressive strength},
language = {eng},
issn = {2187-0764},
journal = {JOURNAL OF ASIAN CERAMIC SOCIETIES},
title = {Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation},
url = {https://www.tandfonline.com/doi/full/10.1080/21870764.2022.2053278},
volume = {10},
year = {2022}
}
TY - JOUR
ID - 2215482
AU - Novotna, Lenka - Chlup, Zdenek - Jaroš, Josef - Částková, Klára - Drdlik, Daniel - Pospíšil, Jakub - Hampl, Aleš - Koutná, Irena - Cihlar, Jaroslav
PY - 2022
TI - Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation
JF - JOURNAL OF ASIAN CERAMIC SOCIETIES
VL - 10
IS - 2
SP - 356-369
EP - 356-369
PB - TAYLOR & FRANCIS LTD
SN - 21870764
KW - Bioceramics
KW - scaffold
KW - calcium phosphate
KW - silica
KW - compressive strength
UR - https://www.tandfonline.com/doi/full/10.1080/21870764.2022.2053278
N2 - The positive effect of silica on microstructural, mechanical and biological properties of calcium phosphate scaffolds was investigated in this study. Scaffolds containing 3D interconnected spherical macropores with diameters in the range of 300-770 mu m were prepared by the polymer replica technique. Reinforcement was achieved by incorporating 5 to 20 wt % of colloidal silica into the initial hydroxyapatite (HA) powder. The HA was fully decomposed into alpha and beta-tricalcium phosphate, and silica was transformed into cristobalite at 1200 degrees C. Silica reinforced scaffolds exhibited compressive strength in the range of 0.3 to 30 MPa at the total porosity of 98-40%. At a nominal porosity of 75%, the compressive strength was doubled compared to scaffolds without silica. When immersed into a cultivation medium, the formation of an apatite layer on the surfaces of scaffolds indicated their bioactivity. The supportive effect of the silicon enriched scaffolds was examined using three different types of cells (human adipose-derived stromal cells, L929, and ARPE-19 cells). The cells firmly adhered to the surfaces of composite scaffolds with no sign of induced cell death. Scaffolds were non-cytotoxic and had good biocompatibility in vitro. They are promising candidates for therapeutic applications in regenerative medicine.
ER -
NOVOTNA, Lenka, Zdenek CHLUP, Josef JAROŠ, Klára ČÁSTKOVÁ, Daniel DRDLIK, Jakub POSPÍŠIL, Aleš HAMPL, Irena KOUTNÁ and Jaroslav CIHLAR. Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation. \textit{JOURNAL OF ASIAN CERAMIC SOCIETIES}. ABINGDON: TAYLOR \&{} FRANCIS LTD, 2022, vol.~10, No~2, p.~356-369. ISSN~2187-0764. Available from: https://dx.doi.org/10.1080/21870764.2022.2053278.
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