Sigma receptor as a potential target for cardiac remodelling

NOVÁKOVÁ, Marie and Tibor STRAČINA. Sigma receptor as a potential target for cardiac remodelling. In 14th New Frontiers in Basic Cardiovascular Research. 2022. ISBN 978-80-8240-024-6.

Basic information

• Original name: Sigma receptor as a potential target for cardiac remodelling
• Name in Czech: Sigma receptor jako možný cíl v remodelaci myokardu
• Authors: NOVÁKOVÁ, Marie and Tibor STRAČINA.
• Edition: 14th New Frontiers in Basic Cardiovascular Research, 2022.

Other information

• Type of outcome: Conference abstract
• Confidentiality degree: is not subject to a state or trade secret
• ISBN: 978-80-8240-024-6
• Keywords (in Czech): sigma receptor; remodelace myokardu
• Tags: International impact, Reviewed

Abstract

Although sigma receptors were originally proposed as a new subtype of opioid receptors, intensive research revealed that they represent unique ubiquitous receptors with several subtypes, specific tissue distribution and pluripotent functions. Primarily, they are located on endoplasmic reticulum membrane, where they function as ligand-operated molecular chaperones. In addition, they interact with numerous proteins in other organelles. In the heart muscle, type 1 of sigma receptor dominates. Sigma 1 receptor modulates calcium signalling in cardiomyocytes, regulates response to endoplasmic reticulum stress, and eventually affects function of voltage-gated ion channels. Since recent studies identify crucial role of cardiac sigma receptors in the development of cardiac hypertrophy and heart failure, their targeting may shed light into the processes of cardiac remodelling.

Links

• MUNI/A/1133/2021, interní kód MU: Name: Od buňky k medicíně (Acronym: CELLVIEW)

Investor: Masaryk University

• MUNI/11/SUP/09/2022, interní kód MU: Name: Vliv sociální izolace na remodelaci myokardu – úloha sigma 1 receptorů

Investor: Masaryk University, Start-up