Pollen-Based Magnetic Microrobots are Mediated by Electrostatic
Forces to Attract, Manipulate, and Kill Cancer Cells

J 2022

Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells

MAYORGA-MARTINEZ, Carmen C., Michaela FOJTŮ, Jan VYSKOCIL, Nam-Joon CHO, Martin PUMERA et. al.

Basic information

Original name

Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells

Authors

MAYORGA-MARTINEZ, Carmen C., Michaela FOJTŮ (203 Czech Republic, belonging to the institution), Jan VYSKOCIL (203 Czech Republic), Nam-Joon CHO and Martin PUMERA (203 Czech Republic, guarantor)

Edition

Advanced Functional Materials, Wrinheim, Wiley-VCH Verlag, 2022, 1616-301X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

21002 Nano-processes ;

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 19.000

RIV identification code

RIV/00216224:14110/22:00129685

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/adfm.202207272

UT WoS

000849040300001

Keywords in English

biological microrobots; drug deliveries; hybrid robotics; magnetic micromotors

Abstract

V originále

Naturally occurring micro/nanoparticles provide an incredible array of potential sources when preparing hybrid micro/nanorobots and their intrinsic properties can be exploited as multitasking functionalities of modern robotics as well as ensuring their mass production availability. Herein, magnetic biological bots (BioBots) prepared from defatted sunflower pollen microparticles by ferromagnetic metal layer evaporation on one side of its surface are described. It is demonstrated that the methodology employed introduces magnetic properties to sunflower pollen microparticles-based BioBots and enable their magnetic actuation. Interestingly, as-prepared magnetic sunflower pollen-based BioBots can naturally attract cancer cells due to their opposite charges (positive and negative, respectively). Such attracted cancer cells can then be transported by microrobots. This strong attraction also allows the delivery of drugs intended to kill the cancer cells. Sunflower-based BioBots can be fabricated in large quantities, and are naturally programmable, making them promising candidates for cancer cell therapy.

Links

NU21-08-00407, research and development project

Name: Funkční nanoroboti pro navigovanou kombinovanou nádorovou terapii

Investor: Ministry of Health of the CR, Subprogram 1 - standard

Citovat

MAYORGA-MARTINEZ, Carmen C., Michaela FOJTŮ, Jan VYSKOCIL, Nam-Joon CHO and Martin PUMERA. Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells. Advanced Functional Materials. Wrinheim: Wiley-VCH Verlag, 2022, vol. 32, No 46, p. 1-8. ISSN 1616-301X. Available from: https://dx.doi.org/10.1002/adfm.202207272.

@article{2217057,
   author = {MayorgaandMartinez, Carmen C. and Fojtů, Michaela and Vyskocil, Jan and Cho, NamandJoon and Pumera, Martin},
   article_location = {Wrinheim},
   article_number = {46},
   doi = {http://dx.doi.org/10.1002/adfm.202207272},
   keywords = {biological microrobots; drug deliveries; hybrid robotics; magnetic micromotors},
   language = {eng},
   issn = {1616-301X},
   journal = {Advanced Functional Materials},
   title = {Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/adfm.202207272},
   volume = {32},
   year = {2022}
}

TY  - JOUR
ID  - 2217057
AU  - Mayorga-Martinez, Carmen C. - Fojtů, Michaela - Vyskocil, Jan - Cho, Nam-Joon - Pumera, Martin
PY  - 2022
TI  - Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells
JF  - Advanced Functional Materials
VL  - 32
IS  - 46
SP  - 1-8
EP  - 1-8
PB  - Wiley-VCH Verlag
SN  - 1616301X
KW  - biological microrobots
KW  - drug deliveries
KW  - hybrid robotics
KW  - magnetic micromotors
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adfm.202207272
N2  - Naturally occurring micro/nanoparticles provide an incredible array of potential sources when preparing hybrid micro/nanorobots and their intrinsic properties can be exploited as multitasking functionalities of modern robotics as well as ensuring their mass production availability. Herein, magnetic biological bots (BioBots) prepared from defatted sunflower pollen microparticles by ferromagnetic metal layer evaporation on one side of its surface are described. It is demonstrated that the methodology employed introduces magnetic properties to sunflower pollen microparticles-based BioBots and enable their magnetic actuation. Interestingly, as-prepared magnetic sunflower pollen-based BioBots can naturally attract cancer cells due to their opposite charges (positive and negative, respectively). Such attracted cancer cells can then be transported by microrobots. This strong attraction also allows the delivery of drugs intended to kill the cancer cells. Sunflower-based BioBots can be fabricated in large quantities, and are naturally programmable, making them promising candidates for cancer cell therapy.
ER  -

MAYORGA-MARTINEZ, Carmen C., Michaela FOJTŮ, Jan VYSKOCIL, Nam-Joon CHO and Martin PUMERA. Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells. \textit{Advanced Functional Materials}. Wrinheim: Wiley-VCH Verlag, 2022, vol.~32, No~46, p.~1-8. ISSN~1616-301X. Available from: https://dx.doi.org/10.1002/adfm.202207272.

Detailed Information on Publication Record