NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT
ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND
XII INHIBITORS

D 2022

NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS

HAVRÁNKOVÁ, Eva, Josef JAMPÍLEK, Vladimír GARAJ and Claudiu T. SUPURAN

Basic information

Original name

NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS

Authors

HAVRÁNKOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Josef JAMPÍLEK (203 Czech Republic), Vladimír GARAJ (703 Slovakia) and Claudiu T. SUPURAN (380 Italy)

Edition

Prague, Czech republic, Czech Chemical Society Symposium Series, p. 14-15, 2 pp. 2022

Publisher

Czech Chemical Society

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30107 Medicinal chemistry

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

electronic version available online

References:

URL

RIV identification code

RIV/00216224:14160/22:00126647

Organization unit

Faculty of Pharmacy

ISSN

Keywords in English

carbonic anhydrases; vancomycin-resistant enterococci; anti-VRE agents; triazinyl-benzenesulfonamides

Abstract

V originále

Carbonic anhydrases (CA, EC 4.2.1.1) are metallo-enzymes present in various organisms. In pathogenic bacteria, CAs play an important role in growth and survival. Inhibition of bacterial CAs leads to growth defects, growth retardation and makes bacterias vulnerable to host defense mechanisms. Bacterial CAs are therefore a very promising target in the search for new antibiotics. A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs were synthesized as potential bacterial CAs inhibitors. Newly prepared compounds have a great potential as antibacterial agents with high activity and at the same time with high selectivity for bacterial CA in comparison with metabolically important hCA isoenzymes (e.g. hCA I, hCA II) found in the human body.

Links

MUNI/A/1202/2020, interní kód MU

Name: Syntéza nových potenciálních inhibitorů CA

Investor: Masaryk University

Citovat

HAVRÁNKOVÁ, Eva, Josef JAMPÍLEK, Vladimír GARAJ and Claudiu T. SUPURAN. NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS. Online. In Radmila Řápková, Martin Fusek, Pavel Drašar. Czech Chemical Society Symposium Series. Prague, Czech republic: Czech Chemical Society, 2022, p. 14-15. ISSN 2336-7210.

@inproceedings{2217366,
   author = {Havránková, Eva and Jampílek, Josef and Garaj, Vladimír and Supuran, Claudiu T.},
   address = {Prague, Czech republic},
   booktitle = {Czech Chemical Society Symposium Series},
   editor = {Radmila Řápková, Martin Fusek, Pavel Drašar},
   keywords = {carbonic anhydrases; vancomycin-resistant enterococci; anti-VRE agents; triazinyl-benzenesulfonamides},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Prague, Czech republic},
   pages = {14-15},
   publisher = {Czech Chemical Society},
   title = {NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS},
   url = {http://www.ccsss.cz/index.php/ccsss/issue/view/31/45},
   year = {2022}
}

TY  - JOUR
ID  - 2217366
AU  - Havránková, Eva - Jampílek, Josef - Garaj, Vladimír - Supuran, Claudiu T.
PY  - 2022
TI  - NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS
PB  - Czech Chemical Society
CY  - Prague, Czech republic
KW  - carbonic anhydrases
KW  - vancomycin-resistant enterococci
KW  - anti-VRE agents
KW  - triazinyl-benzenesulfonamides
UR  - http://www.ccsss.cz/index.php/ccsss/issue/view/31/45
N2  - Carbonic anhydrases (CA, EC 4.2.1.1) are metallo-enzymes present in various organisms. In pathogenic bacteria, CAs play an important role in growth and survival. Inhibition of bacterial CAs leads to growth defects, growth retardation and makes bacterias vulnerable to host defense mechanisms. Bacterial CAs are therefore a very promising target in the search for new antibiotics. A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs were synthesized as potential bacterial CAs inhibitors. Newly prepared compounds have a great potential as antibacterial agents with high activity and at the same time with high selectivity for bacterial CA in comparison with metabolically important hCA isoenzymes (e.g. hCA I, hCA II) found in the human body.
ER  -

HAVRÁNKOVÁ, Eva, Josef JAMPÍLEK, Vladimír GARAJ and Claudiu T. SUPURAN. NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS. Online. In Radmila Řápková, Martin Fusek, Pavel Drašar. \textit{Czech Chemical Society Symposium Series}. Prague, Czech republic: Czech Chemical Society, 2022, p.~14-15. ISSN~2336-7210.

Detailed Information on Publication Record