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@inproceedings{2217368,
author = {Onuščáková, Magdaléna and Pížová, Hana and Kauerová, Tereza and Hamšíková, Marie and Bednář, David and Kollár, Peter and Bobáľ, Pavel},
address = {Pague, Czech republic},
booktitle = {Czech Chemical Society Symposium Series},
editor = {Radmila Řápková, Martin Fusek, Pavel Drašar},
keywords = {HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer},
howpublished = {elektronická verze "online"},
language = {eng},
location = {Pague, Czech republic},
pages = {28-29},
publisher = {Czech Chemical Society},
title = {DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS},
url = {http://www.ccsss.cz/index.php/ccsss/issue/view/31/45},
year = {2022}
}
TY - JOUR
ID - 2217368
AU - Onuščáková, Magdaléna - Pížová, Hana - Kauerová, Tereza - Hamšíková, Marie - Bednář, David - Kollár, Peter - Bobáľ, Pavel
PY - 2022
TI - DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS
PB - Czech Chemical Society
CY - Pague, Czech republic
KW - HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer
UR - http://www.ccsss.cz/index.php/ccsss/issue/view/31/45
N2 - Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking.
ER -
ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Marie HAMŠÍKOVÁ, David BEDNÁŘ, Peter KOLLÁR and Pavel BOBÁĽ. DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS. Online. In Radmila Řápková, Martin Fusek, Pavel Drašar. \textit{Czech Chemical Society Symposium Series}. Pague, Czech republic: Czech Chemical Society, 2022, p.~28-29. ISSN~2336-7202.
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