DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS
NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN
CANCER CELLS

D 2022

DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS

ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Marie HAMŠÍKOVÁ, David BEDNÁŘ et. al.

Basic information

Original name

DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS

Authors

ONUŠČÁKOVÁ, Magdaléna (703 Slovakia, guarantor, belonging to the institution), Hana PÍŽOVÁ (203 Czech Republic, belonging to the institution), Tereza KAUEROVÁ (203 Czech Republic, belonging to the institution), Marie HAMŠÍKOVÁ (203 Czech Republic, belonging to the institution), David BEDNÁŘ (203 Czech Republic, belonging to the institution), Peter KOLLÁR (203 Czech Republic, belonging to the institution) and Pavel BOBÁĽ (703 Slovakia, belonging to the institution)

Edition

Pague, Czech republic, Czech Chemical Society Symposium Series, p. 28-29, 2 pp. 2022

Publisher

Czech Chemical Society

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30107 Medicinal chemistry

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

electronic version available online

References:

URL

RIV identification code

RIV/00216224:14160/22:00126649

Organization unit

Faculty of Pharmacy

ISSN

Keywords in English

HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer

Abstract

V originále

Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking.

Links

MUNI/A/1598/2020, interní kód MU

Name: Analýza antiproliferačních, proapoptotických a cytodiferenciačních účinků nově syntetizovaných hydroxamových kyselin

Investor: Masaryk University

MUNI/IGA/1339/2021, interní kód MU

Name: Design, synthesis and evaluation of potential metalloenzymes inhibitors (Acronym: DSEPMI)

Investor: Masaryk University

Citovat

ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Marie HAMŠÍKOVÁ, David BEDNÁŘ, Peter KOLLÁR and Pavel BOBÁĽ. DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS. Online. In Radmila Řápková, Martin Fusek, Pavel Drašar. Czech Chemical Society Symposium Series. Pague, Czech republic: Czech Chemical Society, 2022, p. 28-29. ISSN 2336-7202.

@inproceedings{2217368,
   author = {Onuščáková, Magdaléna and Pížová, Hana and Kauerová, Tereza and Hamšíková, Marie and Bednář, David and Kollár, Peter and Bobáľ, Pavel},
   address = {Pague, Czech republic},
   booktitle = {Czech Chemical Society Symposium Series},
   editor = {Radmila Řápková, Martin Fusek, Pavel Drašar},
   keywords = {HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Pague, Czech republic},
   pages = {28-29},
   publisher = {Czech Chemical Society},
   title = {DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS},
   url = {http://www.ccsss.cz/index.php/ccsss/issue/view/31/45},
   year = {2022}
}

TY  - JOUR
ID  - 2217368
AU  - Onuščáková, Magdaléna - Pížová, Hana - Kauerová, Tereza - Hamšíková, Marie - Bednář, David - Kollár, Peter - Bobáľ, Pavel
PY  - 2022
TI  - DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS
PB  - Czech Chemical Society
CY  - Pague, Czech republic
KW  - HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer
UR  - http://www.ccsss.cz/index.php/ccsss/issue/view/31/45
N2  - Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking.
ER  -

ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Marie HAMŠÍKOVÁ, David BEDNÁŘ, Peter KOLLÁR and Pavel BOBÁĽ. DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS. Online. In Radmila Řápková, Martin Fusek, Pavel Drašar. \textit{Czech Chemical Society Symposium Series}. Pague, Czech republic: Czech Chemical Society, 2022, p.~28-29. ISSN~2336-7202.

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