HAVRÁNKOVÁ, Eva, Josef JAMPÍLEK, Jozef CSÖLLEI, Vladimír GARAJ and Claudiu T. SUPURAN. NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS. In SAL 2022. 2022.
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Basic information
Original name NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS
Authors HAVRÁNKOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Josef JAMPÍLEK (703 Slovakia), Jozef CSÖLLEI (203 Czech Republic), Vladimír GARAJ (703 Slovakia) and Claudiu T. SUPURAN (380 Italy).
Edition SAL 2022, 2022.
Other information
Original language English
Type of outcome Presentations at conferences
Field of Study 30107 Medicinal chemistry
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14160/22:00126653
Organization unit Faculty of Pharmacy
Keywords in English carbonic anhydrases; vancomycin-resistant enterococci; anti-VRE agents; triazinyl-benzenesulfonamides
Changed by Changed by: RNDr. Eva Havránková, Ph.D., učo 326894. Changed: 13/9/2022 14:19.
Abstract
Carbonic anhydrases are metalloenzymes catalysing the reversible hydration of CO2, thereby affect the pH and affecting related physiological processes in various organisms. In pathogenic bacteria, CAs play an important role in survival and growth. Inhibition of bacterial CAs leads to growth retardation, growth defects and makes bacteria vulnerable to host defense mechanisms. Bacterial CAs are therefore a very promising target in the search for new antibiotics.
Links
MUNI/A/1202/2020, interní kód MUName: Syntéza nových potenciálních inhibitorů CA
Investor: Masaryk University
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