k 2022

DETERMINATION OF INHIBITORY ACTIVITY OF AMINOPEPTIDASE N BY USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

BALLAYOVÁ, Veronika, Radka ŽÁČKOVÁ and Oldřich FARSA

Basic information

Original name

DETERMINATION OF INHIBITORY ACTIVITY OF AMINOPEPTIDASE N BY USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

Authors

BALLAYOVÁ, Veronika (703 Slovakia, guarantor, belonging to the institution), Radka ŽÁČKOVÁ (203 Czech Republic, belonging to the institution) and Oldřich FARSA (203 Czech Republic, belonging to the institution)

Edition

2022

Other information

Language

English

Type of outcome

Prezentace na konferencích

Field of Study

30107 Medicinal chemistry

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14160/22:00126657

Organization unit

Faculty of Pharmacy

ISBN

978-80-280-0105-6

Keywords in English

Leucine aminopeptidase;Aminopeptidase N;AP-N;HPLC assay
Změněno: 30/3/2023 13:27, Mgr. Veronika Murgašová

Abstract

V originále

Leucine aminopeptidases (LAPs) are metallopeptidases that cleave N-terminal residues from proteins and peptides. Aminopeptidase N (AP-N), or membrane alanyl aminopeptidase (m-AAP) is a neutral zinc-binding metalloenzyme. This enzyme is widespread, but is particularly abundant in the brush border membranes of kidney, small intestine and placenta and is also rich in liver. AP-N also turns out to be identical with the human cluster differentiation antigen CD13 expressed on the surface of myeloid progenitors and myeloid leukemia cells. Potential inhibitors of AP-N may offer effective and broad-spectrum therapy for indications such as inflammatory disease or pain management.

Links

MUNI/IGA/0932/2021, interní kód MU
Name: Basic ketones and their derivatives as potential anti-infective and anti-tumor drugs
Investor: Masaryk University