SAL, Ertan, Jannik STEMLER, Jon SALMANTON-GARCIA, Iker FALCES-ROMERO, Laszlo KREDICS, Elisabeth MEYER, Benjamin WUERSTL, Cornelia LASS-FLOERL, Zdeněk RÁČIL, Nikolay KLIMKO, Simone CESARO, Anupma Jyoti KINDO, Hilmar WISPLINGHOFF, Philipp KOEHLER, Oliver A. CORNELY a Danila SEIDEL. Invasive Trichoderma spp. infections: clinical presentation and outcome of cases from the literature and the FungiScope(R) registry. Journal of Antimicrobial Chemotherapy. OXFORD: Oxford University Press, roč. 77, č. 10, s. 2850-2858. ISSN 0305-7453. doi:10.1093/jac/dkac235. 2022.
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Základní údaje
Originální název Invasive Trichoderma spp. infections: clinical presentation and outcome of cases from the literature and the FungiScope(R) registry
Autoři SAL, Ertan, Jannik STEMLER, Jon SALMANTON-GARCIA, Iker FALCES-ROMERO, Laszlo KREDICS, Elisabeth MEYER, Benjamin WUERSTL, Cornelia LASS-FLOERL, Zdeněk RÁČIL (203 Česká republika, domácí), Nikolay KLIMKO, Simone CESARO, Anupma Jyoti KINDO, Hilmar WISPLINGHOFF, Philipp KOEHLER, Oliver A. CORNELY a Danila SEIDEL (garant).
Vydání Journal of Antimicrobial Chemotherapy, OXFORD, Oxford University Press, 2022, 0305-7453.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30104 Pharmacology and pharmacy
Stát vydavatele Velká Británie a Severní Irsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 5.200
Kód RIV RIV/00216224:14110/22:00126680
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1093/jac/dkac235
UT WoS 000836090400001
Klíčová slova anglicky Invasive Trichoderma spp. infections
Štítky 14110515, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Tereza Miškechová, učo 341652. Změněno: 3. 4. 2023 10:22.
Anotace
Background Trichoderma spp. are filamentous fungi causing invasive fungal diseases in patients with haematological malignancies and in peritoneal dialysis patients. Objectives To analyse clinical presentation, predisposing factors, treatment and outcome of Trichoderma infections. Methods A systematic literature review was conducted for published cases of invasive Trichoderma infection in PubMed until December 2021 and by reviewing the included studies' references. Cases from the FungiScope(R) registry were added to a combined analysis. Results We identified 50 invasive infections due to Trichoderma species, including 11 in the FungiScope(R) registry. The main underlying conditions were haematological malignancies in 19 and continuous ambulatory peritoneal dialysis (CAPD) in 10 cases. The most prevalent infection sites were lung (42%) and peritoneum (22%). Systemic antifungal therapy was administered in 42 cases (84%), mostly amphotericin B (n = 27, lipid-based formulation 13/27) and voriconazole in 15 cases (30%). Surgical interventions were performed in 13 cases (26%). Overall mortality was 48% (n = 24) and highest for allogeneic HSCT and solid organ transplantation (SOT) recipients [80% (4/5) and 77% (7/9), respectively]. In patients treated with amphotericin B, voriconazole and caspofungin, mortality was 55% (15/27), 46% (7/15) and 28% (2/7), respectively. Three out of four patients treated with a combination therapy of voriconazole and caspofungin survived. Conclusions Despite treatment with antifungal therapies and surgery, invasive Trichoderma infections are life-threatening complications in immunocompromised patients, especially after HSCT and SOT. In addition, Trichoderma spp. mainly affect the lungs in patients with haematological malignancies and the peritoneum in CAPD patients.
VytisknoutZobrazeno: 28. 3. 2024 13:49