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@inproceedings{2220077,
author = {Pindjaková, Dominika and Hegeduš, Marina and Vráblová, Lucia and Goněc, Tomáš and Jampílek, Josef},
address = {Praha},
booktitle = {Proceedings of the 18th International Students Conference “Modern Analytical Chemistry”},
editor = {Karel Nesměrák},
keywords = {carbamates; HPLC; phenyl-based stationary phases; stability},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Praha},
isbn = {978-80-7444-093-9},
pages = {1-6},
publisher = {Charles University, Faculty of Science},
title = {Evaluation of the stability of biologically active chlorinated arylcarbamoylnaphthalenylcarbamates by RP-HPLC},
url = {http://web.natur.cuni.cz/analchem/isc/isc18.pdf},
year = {2022}
}
TY - JOUR
ID - 2220077
AU - Pindjaková, Dominika - Hegeduš, Marina - Vráblová, Lucia - Goněc, Tomáš - Jampílek, Josef
PY - 2022
TI - Evaluation of the stability of biologically active chlorinated arylcarbamoylnaphthalenylcarbamates by RP-HPLC
PB - Charles University, Faculty of Science
CY - Praha
SN - 9788074440939
KW - carbamates
KW - HPLC
KW - phenyl-based stationary phases
KW - stability
UR - http://web.natur.cuni.cz/analchem/isc/isc18.pdf
N2 - The original carbamates with excellent antimicrobial activity derived from 1-hydroxy-N-(2,4,5-trichlorophenyl)-2-naphthamide were investigated for their stability. 2-[N-(2,4,5-Trichlorophenyl)- carbamoyl]naphthalen-1-yl ethyl carbamate with the weakest steric protection, i.e., with the expected highest degradability and two other carbamates with a more sterically protected carbamate bond (2-[N-(2,4,5-trichlorophenyl)carbamoyl]naphthalen-1-yl 2-phenylethyl carbamate and 2-[N-(2,4,5-trichlorophenyl)carbamoyl]- naphthalen-1-yl isopropyl carbamate), i.e., with the expected lower degradability, were chosen. The developed HPLC methods using chromatographic columns with phenyl-based stationary phases and acetonitrile:phosphate buffer (pH = 2.5) as the mobile phases provided sufficient resolution between the studied carbamates and expected degradant, pattern anilide.
ER -
PINDJAKOVÁ, Dominika, Marina HEGEDUŠ, Lucia VRÁBLOVÁ, Tomáš GONĚC and Josef JAMPÍLEK. Evaluation of the stability of biologically active chlorinated arylcarbamoylnaphthalenylcarbamates by RP-HPLC. In Karel Nesměrák. \textit{Proceedings of the 18th International Students Conference “Modern Analytical Chemistry”}. Praha: Charles University, Faculty of Science, 2022, p.~1-6, 78 pp. ISBN~978-80-7444-093-9.
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