Prognostic factors for survival in patients with unresectable cancer of biliary origin treated with percutaneous transhepatic drainage

ROHAN, Tomáš, Peter MATKULČÍK, Michal UHER, Barbora ČECHOVÁ, Matej STRAKA, Vlastimil VÁLEK, Tomáš KLAIL, Dominika ROSINOVÁ and Tomáš ANDRAŠINA. Prognostic factors for survival in patients with unresectable cancer of biliary origin treated with percutaneous transhepatic drainage. In CIRSE 2022. 2022. Available from: https://dx.doi.org/10.1007/s00270-022-03246-4.

Basic information

• Original name: Prognostic factors for survival in patients with unresectable cancer of biliary origin treated with percutaneous transhepatic drainage
• Authors: ROHAN, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Peter MATKULČÍK (703 Slovakia, belonging to the institution), Michal UHER (203 Czech Republic), Barbora ČECHOVÁ (203 Czech Republic, belonging to the institution), Matej STRAKA (703 Slovakia, belonging to the institution), Vlastimil VÁLEK (203 Czech Republic, belonging to the institution), Tomáš KLAIL (203 Czech Republic, belonging to the institution), Dominika ROSINOVÁ (703 Slovakia, belonging to the institution) and Tomáš ANDRAŠINA (703 Slovakia, belonging to the institution).
• Edition: CIRSE 2022, 2022.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30224 Radiology, nuclear medicine and medical imaging
• Country of publisher: Spain
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14110/22:00126760
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s00270-022-03246-4
• UT WoS: 000852601000002
• Keywords in English: biliary cancer; percutaneous transhepatic drainage; risk factors; survival
• Tags: rivok

Abstract

Purpose: To identify factors affecting survival in patients with unresectable cancer of biliary origin treated with percutaneous transhepatic drainage (PTD). Materials and Methods: This single-centre retrospective study included 233 consecutive patients undergoing PTD for cancer of biliary origin at a tertiary referral hospital from 1/2005 to 12/2019. Cox regression model was used to assess variables related to overall survival after initial PTD. The variables included demographic (age, sex), imaging (mass forming vs. infiltrative, size of mass forming tumor, localisation, Bismuth-Corlette classification in hilar tumors, presence of metastasis), laboratory (bilirubin, liver enzymes and inflammatory markers before and 3-7 days after the procedure, and hemoglobin, thrombocytes, urea and creatinine before the procedure), and treatment parameters of PTD (number of percutaneous drains, presence and number of implanted metal stents, and performance of endobiliary radiofrequency ablation). Results: In multivariate analysis, age (HR 1.23 per 10 years, p=0.005), location (gallbladder cancer HR 2.82 and p<0.001 compared to hilar cancer; common bile duct cancer HR 0.64 and p=0.049; papilla Vateri HR 0.31 and p=0.002), size of the mass (HR 1.07 per cm, p=0.005), level of bilirubin (≥250 umol/L with HR 1.57 and p=0.009) and hemoglobin (≤110 g/L with HR 1.93 and p=0.001) were shown to be significant factors affecting survival in patients with cancer of biliary origin since first PTD. Conslusion: Age, tumour location, mass size, bilirubin and hemoglobin levels before the first PTD have been shown to be significant prognostic factors for survival in patients with cancer of biliary origin treated with PTD.

Links

• MUNI/A/1388/2021, interní kód MU: Name: Význam radiologických intervencí a pokročilých zobrazovacích metod v diagnostice a léčbě pacientů s maligním onemocněním

Investor: Masaryk University

• NU21-08-00561, research and development project: Name: Využití ireverzibilní elektroporace a vysokofrekvenční ireverzibilní elektroporace k léčbě okluzí metalických stentů

Investor: Ministry of Health of the CR, Subprogram 1 - standard